LCMS-2020 Single Quadrupole Liquid Chromatograph Mass Spectrometer (LC/MS)
High-speed LC/MS Analysis with Unrivaled Sensitivity


From HPLC to LCMS, with LCMS-2020

LCMS-2020 + DUIS-2020

The DUIS-2020 is an optional dual ion source for the LCMS-2020. The dual ion source simultaneously performs two types of ionization, ESI and APCI, which allows measuring samples suited to either ionization method at the same time.
This increases the efficiency of ionizing wide ranges of unknown samples, such as when analyzing synthetic compounds. It is particularly useful for confirming synthetic compounds, such as in departments of pharmaceutical companies that are synthesizing new drugs or in departments synthesizing chemical products, or for confirming reaction byproducts and other unknown substances. (LCMSsolution Version 5 or later)

Operating Principle and Structure of Dual Ion Source

Dual ion sources simultaneously ionize samples using two ionization methods - electrospray ionization (ESI), which is suitable for high polarity compounds, and atmospheric pressure chemical ionization (APCI), which is suitable for low-to-medium polarity compounds. Therefore, it is well suited to ionizing a wide range of compounds, with polarity ranging from low to high.

Samples sent to the dual ion source are ionized by an electrospray ionization (ESI) probe, then simultaneously ionized by an atmospheric pressure chemical ionization (APCI) corona discharge needle located beyond the ESI probe. This is useful when it is desirable to analyze two types of compounds, suited to ESI or APCI, at the same time. In addition, since the DUIS-2020 does not use a method of switching between ESI and APCI, it can measure samples with high reliability and reproducibility without any loss of sampling points, even for analyses with narrow peaks obtained using an ultra fast liquid chromatograph.

The DUIS-2020 dual ion source has a simple structure and is easy to maintain. This ion source comes standard with an ESI probe as an ionization probe.
The DUIS-2020 can be controlled and its data processed using LCMSsolution software for LCMS-2020 systems.

Enables ESI, APCI, Positive, or Negative Ionization All at the Same Time

Significantly Improves the Efficiency of Analyzing a Wide Variety of Compounds at the Same Time or Analyzing Unknown Compounds
The following is an example of analysis using the dual ion source. Good response can be obtained for riboflavin by applying a protonated molecule and using ESI, but it is detected only slightly using APCI. A good response can also be obtained for thiamin using ESI, but it cannot be detected using APCI. In contrast, for calciferol, the protonated molecule can be detected using APCI, but ionization by ESI is inadequate. In this case, using the dual ion source enables obtaining a well balanced chromatogram. In addition, the high quality spectrum it provides is as good as one obtained using a specialized ion source.

MS Chromatograms Obtained Using the DUIS-2020

Spectra Obtained Using the DUIS-2020

This ion source is ideal for confirming the molecular weights of synthesized compounds or for simultaneously analyzing a wide range of compounds with polarity ranging from low to high. It also offers higher sensitivity (based on 2006 study) than other commercially available systems in its class. For some samples, however, sensitivity is lower than using the standard ESI or APCI ion source on the LCMS-2020. Therefore, for high sensitivity analysis, the standard ion source may be better for some samples.

For Research Use Only. Not for use in diagnostic procedures.