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Laboratory Instruments

Nanotrap Biomarker Discovery Platform

Nanotrap Biomarker Discovery Platform

Enrich, Preserve and Screen Low-level Biomarkers Directly from Complex Biological Samples

The discovery and validation of better biomarkers has been hindered by several issues, such as complex fractionation and enrich­ment, difficult-to-analyze low-level compounds, and samples that may contain many abundant proteins. With the Nanotrap™ Biomarker Discovery Platform, a partnership between Shimadzu Scientific Instruments, Ceres Nanosciences, and Nonlinear Dynamics, a comprehensive solution to meet Biomarker Discovery challenges is now available.

Platform Components

This fully integrated biomarker discovery platform includes three components for rapid and reproducible results:

Nanotraps are core shell hydrogel particles with porous interiors containing various affinity selector baits and size exclusion exteriors. These particles simplify fractionation and enrichment by serving as molecular mops that provide multidimensional enrichment in one rapid step.

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Nanotrap Advantages

  • One-step fractionation and enrichment
  • Bind low-level compounds
  • Exclude undesired molecules
  • Automated sample processing
  • Protect trapped analytes from degradation

Once samples are enriched, they are eluted from the nanoparticles and spotted directly onto a MALDI plate with matrix. When used with the AXIMA Series MALDI mass spectrometers, Nanotrap-enriched samples are analyzed rapidly and reproducibly in a fully automated format. Additionally, disposable Fleximass-DS targets are available for contamination-free analysis and sample archiving.

After data is acquired, it can be analyzed using the Progenesis MALDI software. Progenesis MALDI generates high-quality proteomics data to define biomarkers. It uses the unique Progenesis approach and technology to improve the reliability and reproducibility of results and adds speed, objectivity and statistics to biomarker discovery.

Shown here is an example of the enrichment of PDGF using Nanotraps.


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Give the Nanotrap™ Biomarker Discovery Platform a try. Contact us today to set up a trial!

Related Article(s)

Biomarkers for Disease Identification (PDF - 140 KB)
Shimadzu protein instruments open new avenues to speed biomarkers to the clinic

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