High Speed Analysis of Phenytoin in Accordance with Chapter 621 in USP 39

High throughput analysis has been advanced dramatically in recent years with the increasing necessity to improve productivity and operational efficiency. Especially HPLC has also been in the spotlight thanks to significant advances in ultra-high-speed analysis technology, in particular ultra-high performance LC and micro-particle column packing material. The recently revised General Chapter 621 of the United States Pharmacopoeia (USP 621) now permits a degree of adjustment of HPLC and GC parameters, specifically aimed to satisfy the requirements of system suitability. Taken account of USP 621, this Application News introduces an example of isocratic analysis of Phenytoin monograph in accordance with USP and still fulfilling the allowable adjustment criteria. Phenytoin is an anti-seizure medicament. It is used for the prevention of seizures and for status epilepticus. An example of analysis that can be completed in a significantly shorter time than that described in the USP General Chapter 621 is presented here.

Content Type:
Application News
Document Number:
SCA-190-040
Product Type:
High Performance Liquid Chromatography (HPLC & UHPLC)
Keywords:
Phenytoin, usp 39, chapter 621, Pharma & Biopharma, QA/QC Manufacturing, LC-2040C 3D
Language:
English
File Name:
SCA-190-040-High-Speed-Analysis-Phenytoin-Chapter621-USP39.pdf
File Size:
366kb

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For Research Use Only. Not for use in diagnostic procedures.

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