Disulfide Bond Characterization of Monoclonal Antibody (mAb) using Q-TOF Mass Spectrometer

A straight forward LCMS-based method for accurate disulfied bond peptide characterization of mAb biosimilar was established on LCMS-9030. The MS/MS spectra with fragmentation data provide high confidence results on sequencing analysis. The demonstrated performance for bevacizumb biosimilar in detection an de novo sequencing of non-reduced and deduced disulfide bonds signifies its practicability for the structural characterization of mAb biosimilars.

Content Type:
Application News
Document Number:
AD-0214
Product Type:
Liquid Chromatography Mass Spectrometry (LC-MS)
Keywords:
monoclonal antibody, mab, disulfide bond, q-tof, biotherapeutics, Pharma & Biopharma, Monoclonal Antibodies and Biosimilars, LCMS-9030
Language:
English
File Name:
Shimadzu-ad-0214.pdf
File Size:
401kb

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For Research Use Only. Not for use in diagnostic procedures.

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