The Environmental Protection Agency (EPA) has recently published draft SW-846 Method 8327 for the analysis of PFAS in groundwater, surface water,and wastewater. No other EPA method for PFAS analysis in complex matrices was available; hence,this method in its final version will provide a tool for monitoring selected PFAS in non-potable waters. This application note demonstrates that the LCMS-8050 meets and exceeds the Quality Assurance and Quality Control criteria specified in the method. All analytes were reliably quantitated at or less than 5ppt. Ultimately, this work provides a fast and robust solution for addressing the challenges in the quantitation of low levels of PFAS in non-potable waters.