Determination of Perchlorate in Drinking Water using Suppressed Anion Chromatography Coupled with Single Quadrupole MS

Perchlorate is considered toxic in that it may cause dysfunction of the thyroid gland and may lead to a reduction of thyroid hormones Despite current lack of regulation at federal level, there are several states where perchlorate needs to be monitored in drinking water to ensure compliance with the corresponding Maximum Contaminant Levels A few perchlorate determination methods have been developed by the U S Environmental Protection Agency ( EPA Method 332 0 is one of the most sensitive methods using suppressed ion chromatography coupled with mass spectrometry In this study, an IC MS method was developed using a novel electrolytically regenerated anion suppressor as a part of a modular IC system coupled with a LC MS 2020 single quadrupole MS to achieve higher sensitivity and selectivity for perchlorate determination in drinking water Both conductivity detection ( and MS with electrospray ionization ( are used in the method The CDD is used to monitor the column effluent, only the perchlorate fraction is directed to MS via a divert valve Two predominant perchlorate ions are 35 Cl 16 O 4 and 37 Cl 16 O 4 with m/z are 99 and 101 respectively Selected ion monitoring ( of both ions was used in the method The system produced linear response with coefficient of determination greater than 0 9999 from concentration of 0 25 ppb to 20 ppb This study demonstrated the robust and reliable performance of the novel modular IC MS for the determination of perchlorate in drinking water

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High Performance Liquid Chromatography (HPLC & UHPLC), Liquid Chromatography Mass Spectrometry (LC-MS)
Perchlorate, Drinking Water, EPA Method 332.0, Environmental, Prominence Ion Chromatograph, LCMS-2020 Single Quadrupole Liquid Chromatograph Mass Spectrometer (LC/MS)
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