Efficient introduction of ionic compounds into LC-MS using the improved ESI unit; Application to dirty samples

A Newly-developed ionization unit, IonFocus Unit introduces ions into the mass spectrometer more efficiently, while expelling contaminants. To evaluate this unit, we conducted two analyses of samples with complicated matrices. In the ESI (Electrospray Ionization), which is widely used as an ionization method for LC/MS, the sample in a mobile phase is sprayed by applying a high voltage and then it is dried and Ionized. At this time, if not only ions but also contaminants enter the MS, they will contaminate the ion guides and lead to a decrease in sensitivity. They also may be one of the causes of the matrix effect. To prevent these issues, if we set the position of the ion spray far from the inlet of the MS, the sampling efficiency of the target ions is also decrease. This means that there is a trade-off between sensitivity and robustness. In this poster, we show one of the solution for this trade-off.

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Document Number:
ASMS 2020 - WP 344
Product Type:
Liquid Chromatography Mass Spectrometry
Environmental, Food, Beverages, LCMS-8060NX Triple Quadrupole Liquid Chromatograph Mass Spectrometer (LC-MS/MS)
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