A Newly-developed ionization unit, IonFocus Unit introduces ions into the mass
spectrometer more efficiently, while expelling contaminants. To evaluate this
unit, we conducted two analyses of samples with complicated matrices. In the ESI (Electrospray Ionization), which is widely used as an ionization
method for LC/MS, the sample in a mobile phase is sprayed by applying a high
voltage and then it is dried and Ionized. At this time, if not only ions but also
contaminants enter the MS, they will contaminate the ion guides and lead to a
decrease in sensitivity. They also may be one of the causes of the matrix effect.
To prevent these issues, if we set the position of the ion spray far from the inlet
of the MS, the sampling efficiency of the target ions is also decrease. This
means that there is a trade-off between sensitivity and robustness. In this
poster, we show one of the solution for this trade-off.
- Content Type:
- Document Number:
- ASMS 2020 - WP 344
- Product Type:
- Liquid Chromatography Mass Spectrometry
- Environmental, Food, Beverages, LCMS-8060NX Triple Quadrupole Liquid Chromatograph Mass Spectrometer (LC-MS/MS)
- File Name:
- File Size:
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