High Sensitivity Analysis of Steroid Hormones with modified ESI to improve desolvation efficiency

Development of a high-sensitivity method to assay a steroid panel in serum samples. Thanks to LC-MS/MS with the newly developed ion source IonFocus Unit, the sensitivity of steroid hormone was improved. Steroid hormones play a major role in the control of metabolism, neurotransmission, intracellular signaling, gene expression, reproduction and cardiovascular. Therefore, steroid hormones are very important in elucidating the mechanisms of various diseases. Furthermore, not only do steroids play roles in sedation and seizure prevention, they are known to be effective in cancer treatment and regenerative medicine. Therefore, highly sensitive analytical technologies to steroid hormones quantitation in biological samples are required in clinical research. Here we investigated higher sensitive analytical methods to steroid hormones by improving desolvation efficiency in LC-MS/MS ion source.

Content Type:
Poster
Document Number:
ASMS 2020 - WP 350
Product Type:
Liquid Chromatography Mass Spectrometry
Keywords:
Pharma & Biopharma, LCMS-8060NX Triple Quadrupole Liquid Chromatograph Mass Spectrometer (LC-MS/MS)
Language:
English
File Name:
WP350-ASMS-2020-Poster.pdf
File Size:
872kb

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