LC-MS/MS Analysis of Haloacetic Acids with Simplified Sample Preparation

Haloacetic acids ( are known carcinogens that may occur as disinfection byproducts in drinking water Currently five HAAs are regulated under the Stage 2 Disinfectants and Disinfection Byproducts Rule and occurrence of four more HAAs is being monitored under the Unregulated Contaminant Rule 4 2018 2020 ))(Table 1 The vast majority of utilities and environmental commercial laboratories use EPA method 552 3 to ensure monitoring compliance with federal regulations However, this method is tedious and prone to errors due to the complex sample preparation Also, reagents required are potentially harmful for humans and ecosystems if not handled and disposed properly. An easier and faster alternative for the analysis of HAAs is based on the direct injection of the samples onto a LC MS/MS Countries like Japan and others use this method for compliance monitoring of HAAs in drinking water Because of the ease of implementation and fast turn around time of results, this method is a promising alternative for the monitoring of HAAs, especially during events in which increased formation of HAAs could occur (e g chlorine burns, maintenance in water treatment plants and distribution system In this poster, the initial demonstration of the LC MS/MS method performance is presented using the Shimadzu LCMS 8060

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Liquid Chromatography Mass Spectrometry (LC-MS), High Performance Liquid Chromatography (HPLC & UHPLC)
Haloacetic Acids, HAAs, Drinking Water, EPA Method 552.3, Environmental, Nexera (40-Series) UHPLC System, LCMS-8060 LC-MS/MS System
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