Unravelling Tissue Complexity in Samples of Human Inflammatory Bowel Disease Using Imaging Mass Spectrometry

Inflammatory bowel diseases (IBD) such as ulcerative colitis (UC) and Crohn’s disease (CD) are chronic and relapsing inflammatory conditions of unknown aetiology. Current treatments are not universally effective and can have severe adverse effects. Therefore, early detection and precise identification of the type of disease is important in order to apply the correct treatment. Colon tissue is complex and contains different types of cells, and therefore a cell-specific analytical tool is required to improve diagnosis and prognosis. Here we present a mass spectrometry imaging (MSI) study at 10 micron (μm) spatial resolution of endoscopic biopsies obtained from patients with IBD. As lipid composition varies between cell types, the lipid fingerprint may serve as a signature of each type of lesion.

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ASMS 2020 - TP 217
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Life Science, MALDI-TOF Mass Spectrometry
Life Science Solutions, MALDI-7090TM TOF-TOF Mass Spectrometer
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