DPs are typically defined as lacking a fixed structure however there is growing evidence that IDPs play an important role in cell signalling and various pathological states. Misfolding and aggregation of α-synuclein form a major component in Lewy bodies which form the main pathogenesis of Parkinson’s disease (PD) and thus characterisation of differing conformational states of IDPs is vital to the understanding of disorders such as PD. In this work a technique known as FPOP was used to oxidatively modify several model proteins in order to compare modification efficiency of fixed conformation proteins verses the IDP α-synuclein.
- Content Type:
- Document Number:
- ASMS 2020 - MP 521
- Product Type:
- Liquid Chromatography Mass Spectrometry (LC-MS)
- asms 2020, protein, α-synuclein, fpop, lcms, analysis, Parkinson’s, idps, Life Science Solutions, LCMS
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