Analysis of Ions in Drugs (Part 5) Analysis of Organic Acid Counterions by Ion Exclusion Chromatography

Application News No. L457 described an example analysis of chloride, formic acid, acetic acid, andtrifluoroacetic acid ions present in drugs using ion chromatography. As mentioned above, drugs cancontain multiple different counterions and it is sometimes difficult to separate completely the peaks of these ions using ion chromatography. We describe an example analysis that uses ion exclusion chromatography to increase separation selectivity forformic acid, acetic acid, fumaric acid, and maleic acid, which are organic acids frequently used for drug counterions.

Content Type:
Application News
Document Number:
L504
Product Type:
High Performance Liquid Chromatography (HPLC & UHPLC)
Keywords:
Pharmaceuticals
Language:
English
File Name:
L504.pdf
File Size:
756kb

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