Trace analysis of abused drugs in waste water sample by AOE system coupled with LCMS-8060

Pesticides, drugs, pharmaceuticals are widely used in daily life and cause great pollution to water. The development of analytical methods was mainly dictated by their low concentrations found in water. In order to meet the requirement of high sensitivity, sample preparation plays a crucial role in the analytical method. Most of the reported methods used solid-phase extraction when pretreated water samples. However, the offline SPE procedures are time-consuming and error-prone, meaning they require a large amount of organic solvents and have the potential to lose a certain number of analytes The online SPE-LCMS systems, which allowed the entire analytical procedure to be performed in a closed system, reduced sample loss while obtaining high accuracy and repeatability. In this study, an online cross used SPE-UHPLC-MS/MS system named AOE systems (Automatic Online Extraction/Enrichment system), which allowed the automatic cross-utilization of two SPE columns, was developed, validated and applied to analyze 12 kinds of abused drugs in waste water samples. All the methods were fully validated and proved to be accurate, sensitive, and showed good linearity and recovery. The developed method was successfully applied to the real waste water samples analysis.

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Document Number:
ASMS 2020 - MP 318
Product Type:
Liquid Chromatography Mass Spectrometry, Liquid Chromatography
ASMS 2020, LCMS, trace analysis, drugs, waste water, samples, aoe, system, , Forensics, LCMS-8060, SPE
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