Webinars and Online Training - Industries

Webinars and Online Training

Cannabis and Hemp Testing Webinars

Learn more about our Cannabis and Hemp Testing Solutions

Detection of Typical GCMS Pesticides by APCI-LCMS in Cannabis

Presentation topics include: What is MS?, LCMS vs GCMS, Pesticide Analysis in Cannabis, LCMS Source Types, MRM Development and Optimization, Final Method Parameters, Sample Preparation, Matrix Effects, Representative Chromatograms, Calibration Curves, and LOQs

Detection of Typical GCMS Pesticides in Cannabis Webinar 

 

How to Increase Speed and Efficiency of Heavy Metals Testing in Cannabis

Join industry experts from Glass Expansion, CEM, and Shimadzu to learn about methods, optimization, and tips and tricks related to the analysis of heavy metals for the cannabis industry. This discussion will cover the complete analysis process, from digestion to data.

Heavy Metals Cannabis Webinar 

 

NIST Tools for Confidently Distinguishing Between Hemp and Marijuana

This webinar will focus on the analytical methods and procedures being developed at NIST for accurately measuring cannabinoids (THC, THCA, CBD, etc.) in Cannabis samples and the solutions provided by Shimadzu Scientific Instruments.

 

Tips and Tricks: Cannabis Sample Prep and Analysis by ICP-MS

Join us to learn a few tips and tricks to overcome common problems associated with the analysis of cannabis samples by ICP-MS.

ICPMS Tips and Tricks for Cannabis Webinar 

 
 

Clinical Research Webinars

Learn more about our Clinical Research Solutions

Analysis of Steroid Hormones by LC-MS/MS: Advancing Research in HIV/AIDS and Reproductive Health

Steroid hormones are a frequent target of analysis in both basic research and clinical laboratories. LC-MS/MS has become the preferred method of analyzing steroid hormones due to small required sample volumes, ability to multiplex panels of hormones, high throughput, and its improved specificity over immunoassays. This presentation will focus on ways in which the Endocrine Technologies Core at Oregon National Primate Research Center applies LC-MS/MS analysis of steroid hormones to advancing research in HIV/AIDS, reproductive disorders, and contraception. A description of the methods and some of the challenges presented by LC-MS/MS analysis of steroid hormones will be presented. Supported by NIH P51 OD011092 and NIH S10 OD026701.

 

Brace Yourselves: The Shift to Mass Spectrometry for Clinical Analysis

There is a shifting trend in the analytical platform from immunoassay to mass spectrometry in clinical research and diagnostic lab in the past decade. This growing trend of mass spectrometry application in clinical lab is due to the superior selectivity and sensitivity of mass spectrometers. More importantly, mass spectrometry can analyse multiple compounds in a single analysis using much lesser sample amount compared to immunoassay. The application of mass spectrometry in various clinical analysis using Shimadzu’s Ultra Fast Mass Spectrometry (UFMS) Technology will be discussed in this webinar. Lastly, Shimadzu latest innovative technology in clinical automation and rapid screening will also be highlighted.

 

Direct Probe Ionization Mass Spectrometry (DPiMS) for High Throughput Analysis

Evolution of mass spectrometry (MS) hardware, especially ionization method, has drastically changed the landscape of MS applications. Direct Probe Ionization Mass Spectrometer (DPiMS) has the potential to pioneer new types of applications with the new ionization interface. The technique successfully incorporated the best of both worlds; high ionization efficiency of ESI and simplicity of MALDI. This was achieved by using an ultrafine needle to sample an extremely small volume of sample on its surface and subsequently applying high voltage to the needle to imitate an ESI probe. DPiMS is characterized by the microscopic sampling volume and high sensitivity for the amount sampled at a low ng/mL concentration range. For this, DPiMS can be a robust solution for the routine analysis of high-complexity matrices, such as plasma or food extract, as contamination of MS hardware can be perfectly mitigated. Moreover, direct sampling from solid samples causing minimal destruction might enable new applications such as real-time analysis of live tissues or cells.

DPiMS Webinar 

 

Energy & Chemicals Webinars

Learn more about our Energy and Chemicals Solutions

Analysis of Alcohols and Hand Sanitizers – Regulatory Compliance and Analytical Efficiency

In this webinar, our panel of experts will discuss the market for alcohol-based hand sanitizers, the current regulatory environment, as well as analytical solutions including gas chromatography, Fourier-transform infrared spectroscopy, and UV-Vis spectroscopy to ensure the purity, potency, and safety of alcohols and hand sanitizers.

 

Analysis of Siloxanes in Biogas using TD-GC-MS

Simultaneous measurement of total siloxanes in biogas presents several challenges including a wide spectrum of sample matrices, challenging sensitivity requirements, and many sources of sample contamination. The newly developed standard method for sampling and analysis of siloxanes in gaseous fuels is ASTM D8230. In its current form, the method prescribes sampling by tedlar bags, passivated canisters, and sorbent traps with several options for laboratory analysis including GC-MS, GC-ICP-MS, or GC-AED.. In an effort to improve the method, Ohio Lumex has developed a siloxane sorbent trap and analysis procedure using a Shimadzu GCMS-QP2020 NX with TD-30 attachment. Ohio Lumex has also developed other methods allowed by ASTM D8230 on the same instrument to directly compare method performance. This procedure, as well as the advantages it provides over the current procedures described in D8230, will be discussed. 

 

Analysis of Sulfur Compounds in Hydrocarbon Matrices by ASTM D5504, D5623, and D7011 with a new GC-SCD

In this webinar, we will discuss the fundamentals of GC-SCD as well as common challenges, explore the unique design of Shimadzu’s new SCD and how it overcomes these challenges, and present data for this system’s applicability to ASTM D5504, D5623, D7011, as well as quantification of sulfur compounds in ethylene and propylene.

 

Analyzing Aromatics in Jet and Diesel Fuels Using LC-RID

Analysis of the chemical components of fuels is critical to ensuring their quality, combustion characteristics, and compliance with environmental regulations. This webinar will provide a background on the common industry test methods for fuels, the challenges associated with long-standing techniques, and explore Shimadzu’s HPLC-based solutions for the energy industry.

Analyzing Aromatics in Jet and Diesel Fuels Webinar 

 

Comprehensive Analytical Solutions for Lubricant Condition Monitoring

In this webinar hosted by Shimadzu, we will discuss the chemical analysis of lubricants and why these analyses are critical to cost-efficient operation of heavy machinery. Lubricants serve critical functions within an engine or turbine beyond just lubrication, including cleaning, heat transfer, and corrosion prevention, among others. Changes in a lubricant’s chemistry can be indicative of mechanical problems or indicate loss of utility as it can no longer effectively perform the functions for which it was designed. In the context of industry-standard test methods from ASTM, we will cover analytical topics including analysis of soot, moisture, oxidation, and breakdown of additives by using FTIR, analysis of wear metals in lubricants by ICP-OES, and lastly, fuel dilution into lubricants by GC-FID.

 

Expanding Material Characterization Capabilities Using Pyrolysis GCMS

Have you ever wanted an alternate sample introduction method?  Maybe the sample of interest needs to be hotter than a standard inlet will reach.  Pyrolysis is a sample introduction technique that uses elevated temperatures to break down organic materials.  The starting samples can be anything from liquids to solids from many different application areas.  Attend to get your questions answered by the experts.

Material Characterization Capabilities Using Pyrolysis Webinar 

 

Reliable Sulfur Speciation by A Newly Designed GC SCD

This eLearning session introduces the operating principle of the SCD, as well as the innovations brought by Shimadzu to improve the productivity and minimize the instrument downtime. You will learn the various features of Shimadzu SCD which make it a reliable tool for analysing sulfur-containing compounds down to the trace level.

Sulfur Speciation Webinar 

 

RoHS : Regulatory compliance and it's solutions

Complying with the European Union (EU) or India's directive on Restriction of Hazardous Substances (RoHS) is an ongoing challenge for many companies. Too often, their compliance activities are unnecessarily complicated by a lack of understanding about what the regulation requires, and how to stay compliant when new restricted substances are introduced. Here in this webinar, our expert team will try to explain about the latest regulation, its implications, along with easy testing solutions to stay compliant to avoid any enforcement action.

RoHS Webinar 

 

Stay Safe! Comprehensive Analysis of Alcohols and Hand Sanitisers

In this webinar, our panel of experts will discuss the market for alcohol-based hand sanitizers, the current regulatory environment, as well as analytical solutions including gas chromatography, Fourier-transform infrared spectroscopy, and UV-Vis spectroscopy to ensure the purity, potency, and safety of alcohols and hand sanitizers.

 

Supelco’s Watercol™ Ionic Liquid Capillary Columns Coupled with TCD and Shimadzu’s BID for Detection and Quantitative Analysis of Water by Gas Chromatography

The determination of water content in alcoholic beverages, solvents and various consumer products such as foods, fuels, pharmaceuticals, and petroleum products is one of the most common types of chemical testing. Many techniques such as gravimetric analysis, gas chromatography (GC), Karl Fischer Titration, near infra-red spectroscopy, and others have been used for water quantification with good results. However, the limitations of these approaches can include high limits of detection, large sample sizes required for trace analysis, side reactions, the use of expensive consumables, and the production of chemical waste. Previous work by Prof. Daniel Armstrong and co-workers has described the use of ionic liquid GC capillary columns for the trace analysis of the water content in a wide variety of solvents. These columns were capable of providing a rapid and quantitative determination of water contents using very small sample amounts. This webinar further examines the characteristics of ionic liquid capillary columns for the GC analysis of water.

Analysis of Water by GC Webinar 

 

Environmental Webinars

Learn more about our Environmental Solutions

Emerging Water Quality Issues: Are You Ready to Monitor PFAS in your Water?

This webinar discusses the global trends and regulatory requirements pertaining to PFAS analyses (e.g. EPA 537.1) Several case studies on drinking water and environmental matrices are described to illustrate the difficulties and pitfalls of LC-MS/MS analyses and their solutions.

PFAS Webinar 

 

Monitoring and Quantitation of Nitrosamines in Water using GC-MS via Chemical Ionisation

Formation of nitrosamines, particularly NDMA, is prevalent in water treatment plants using chloramine as a disinfectant. NDMA is classified as a B2 carcinogen based on the induction of tumors at multiple sites in different mammal species exposed to NDMA by various routes. EPA 521 has been provided as the validated extraction and analytical procedure for monitoring of nitrosamines in drinking water. However, this method was developed using large volume injections (20 µL) and ion trap spectrometers in MS/MS chemical ionization (CI) mode (with methanol or acetonitrile). To avoid the complexity of large volume injections and CI, we present the alternative gas chromatography triple quadrupole electron ionisation method. Additionally, calibrants were prepared via an auto-sampler, from 1000 µg/ml commercially available standards.

Nitrosamines in Water Webinar 

 

Pyrolysis-GCMS: The Power of Mass Spectroscopy for Unveiling Plastic Contamination in the Environment

In this event, our two speakers will discuss the suitability of this technique for assessing the fate of microplastics in the environment. They will also present examples of how they have applied Py-GCMS for studying these contaminants in water, biosolids and seafood samples, among others.

Unveiling Plastic Contamination in the Environment Webinar 

 

RoHS : Regulatory compliance and it's solutions

Complying with the European Union (EU) or India's directive on Restriction of Hazardous Substances (RoHS) is an ongoing challenge for many companies. Too often, their compliance activities are unnecessarily complicated by a lack of understanding about what the regulation requires, and how to stay compliant when new restricted substances are introduced. Here in this webinar, our expert team will try to explain about the latest regulation, its implications, along with easy testing solutions to stay compliant to avoid any enforcement action.

RoHS Webinar 

 

Subsurface Microbiology: Metabolism by HPLC

Cultivation-independent sequencing techniques have revealed a tremendous diversity of microorganisms on our planet. Although, the majority of microorganisms are not isolated and do not have sequenced genomes. While this applies to all fields of environmental microbiology, it does not prevent research from progressing. Conversely, in the field of subsurface microbiology the dearth of cultured representatives heavily restricts the simplest hypothesis driven experimentation. In this work, we discovered a novel strict anaerobic thermophilic bacterium from a monitoring borehole at a depth of 691 meters below land surface. This borehole is of particular interests as it resides within the US Great Basin, in particular the Nevada National Security Site, underlain by the Death Valley Regional Flow System. The characterized isolate was given the name Thermoanaerosceptrum fracticalcis strain DRI-13T, and the sequenced genome coupled with methylome analysis reveal interesting insights into metabolism/energy conservation, gene regulation, DNA defences, and archival of previous viral aggressions.This microorganism and others have been analysed using HPLC to track substrate utilization and waste product production in order to better understand the syntrophic interactions of subsurface life. The deep biosphere may reveal itself as an untapped resource of microbial biodiversity holding novel solutions to industrial, medical, and potential providing answer to the origins of life.

Subsurface Microbiology Webinar 

 
 

Food & Beverage Analysis Webinars

Learn more about our Food and Beverages Solutions

Authentication of Essential Oils through Chiral GCMS

Essential oils are one of the growing commodity markets in the flavor fragrance and aromatherapy sector. Its demand is increasing since it has fewer side effects than synthetic medicines.  Unfortunately, due to a lack of reliable instrumental techniques and strict government regulation, adulteration of natural products is rampant worldwide: adulteration impacts the therapeutic values of oils and a country’s economy. Tentatively 80% of commercially available, so-called “natural” essential oils are adulterated somehow. Chiral GCMS is one of the most useful and practical applications for the authentication of essential oils. Plants of the specific species from any origins produce the same enantiomeric ratios, which is a crucial indicator of authentication in essential oils. For example, lavender has 95% L linalool, whereas coriander has 84% D linalool, citrus has 99% D limonene, fir needle has 100% L-limonene. Even being the same physicochemical properties, they have distinctly different biological and organoleptic properties. The enantiomer of the same molecule at the same time can be harmless as well as toxic. A chiral GCMS analysis helps detect other species mixing or nature-identical synthetic compound addition in essential oils.

 

Become a Digital Wine Connoisseur - Aroma Characterization using GCMS

Wine is a very delicate agricultural product, whereby, similar grape varieties can achieve very different aromatic profiles due to various cultivation conditions. With these variations, aroma profiling of wine is essential in the production process to identify consumers' preferences, formulating conditions and also quality control. These aromatic profiles are determined by a multitude of volatile compounds which are usually characterized comprehensively using GC/GCMS. In this webinar, Prof. Erich Leitner from Graz University of Technology will share on wine profiling and how GC/GCMS as analytical tool could help on different origin of different wines.

 

Brewing up laboratory skills!

An estimated 97% of the world’s hop crop makes its way into beer. They can be used to add hop flavors, bitterness, and aroma. The aroma properties of hops are one of the most challenging characteristics to standardize. Despite this, many brewers still select their hops by manual sensory evaluation, counting on their experience to ensure the aroma characteristics of the fresh hops result in the desired traits for their beers. As new hop technology has developed however, hundreds of hop oil compounds have been identified and the role of these compounds is no longer limited to aroma. For instance, while a- and b-acids are known to contribute to the aroma, a-acids have been identified as responsible for the bitterness with a specific interest on the ratio of cis/trans iso-a-acids changing as beer ages. Furthermore, recent reports indicate that isohumulones (a class of iso-a-acid) play a role in head retention. Since the conditions of the brewing process can vary wildly from brewery to brewery and the starting materials are dependent upon environmental conditions, the fates of these individual compounds need to be tracked to ensure consistent and reproducible results in the product. Initial results on our collaboration with local craft breweries in the Hampton Roads community will be presented. Additionally, as Christopher Newport University is a primarily undergraduate institution (PUI), efforts to engage students taking analytical chemistry with a real-world application of brewing and testing beer from local breweries will be presented. CNU students gain hands-on laboratory experiences and skills that are extremely desirable to numerous industries. Former research students have been hired by local breweries, the Navy, sanitation departments, and pharmaceutical development companies. In addition to real world experience, our students are engaged with their local community which we, as Captains, seek and hold in our core values.

 

Food Contact Materials: GRAS* or Gross?

Food Contact Materials (FCM) are any materials that come in contact with food during processing, storage, preparation or serving. The safety of these FCMs must be evaluated as they can migrate into the food supply and contaminate the food with compounds like Per-and Polyfluorinated substances (PFAS), mineral oils (MOSH/MOAH), and leachables/extractables from plastics containers (bisphenol A, heavy metals). This webinar will provide an introduction to FCMs, discuss the challenges faced by the food industry, and present the latest analytical technologies for FCMs.

 

For the Love of Food! Food Safety and the Analysis of MCPD in Edible Oils

This webinar will clarify the regulatory status and analytical methods applied for the analysis of monochloropropane diol (MCPD) and glycidol contaminants in edible oils. Join us to learn how oil refining and food processing methods can be modified to minimise the in-situ generation of these contaminants in order to meet the regulatory requirements. While GCMS is the standard instrumentation to monitor the levels of these contaminants, multiple sample preparation steps must be adhered to in the various AOCS official methods. Find out how GERSTEL and Shimadzu come together to deliver the best automated solution for your food safety analysis needs. For the love of food!

 

LC-MS/MS methods for vitamin B and D analyses as per AOAC methods in infant and adult formulae

Vitamin B and D are important micronutrients to maintain good health. They are often fortified in various foods such as infant and adult formulae for added health benefits. Over the years, there are many AOAC methods dedicated to the analyses of different vitamin B and vitamin D compounds in infant and adult formulae. In recent years, many AOAC methods use LC-MS/MS to analyse both these vitamins. In this webinar, I will discuss about the different AOAC methods and the sample preparations in the analysis of vitamin B and D. I will also share some of the application development works done closely following AOAC methods using Shimadzu LC-MS/MS. 

 

Online Derivatization and UHPLC Analysis of Total Amino Acids in Animal Feed

This webinar gives you an introduction on fully automated pre-column derivatization of the amino acids and microwave digestion method which were adopted to further speed up and increase the analysis efficiency. A Shimadzu Nexera LC-40X3 with photodiode array (PDA) and fluorescence (RF) detectors were employed for the analysis. The Nexera LC-40X3 equipped with automated pre-treatment function allows several derivatization reagents to be aspirated sequentially from multiple vials and mixing within the needle and the sample loop. Microwave digestion procedure was employed to carry out both acid and alkaline hydrolysis in less than 30 minutes, which is much faster in comparison to the conventional hydrolysis up to 24 hours. Fluorescent (RF) detection was used for high sensitivity analysis (nM), while UV detection was compared, which shows its applicability for µM level quantitation of amino acids.

 

Shimadzu GC-MS/MS Solutions for Food Safety

This webinar provides a glimpse of the cutting-edge technology Shimadzu GCMSMS offers in the field of food safety. Agricultural industry faces a huge challenge of producing increasing quantities of food. While meeting such expanding global food demand, the safety and sustainability of food supply is of utmost importance. With the use of chemicals, significant reduction in crop losses and thus increased yield has been achieved. However, the resulting pesticide residues is of growing concern with its potential health risks. The exponential growth of chemical hazards and their regulations have brought several challenges to the food safety industry. It is particularly challenging for laboratories to accurately analyse large amounts of samples and detect the non-compliant ones. Understanding current laboratory requirements, GCMS-NX series along with its robust and sensitive hardware provides simplified user-friendly software for handling large multi-component data. Along with the unmatched hardware performance, Shimadzu also offers customizable databases and method packages as a total solution. 

 

Solutions for Halal Testing

In recent years, unauthorized blending of undeclared materials into food products has been a major concern among consumers. Such action violates customer rights based upon economical and safety values and it is also a critical problem for communities with ethical and religious belief. Both accidental and intentional adulteration of pork materials or alcohol into food and beverages are significant issue affecting Muslims as they have dietary restrictions on foods containing alcohol, pork and its-by-product, such as gelatin. With an estimated 1.6 billion Muslims worldwide, development of sensitive method for detection of porcine materials in food products is indispensable. In this webinar, we present Shimadzu complete solution for Halal testing.

 

Spice Up Your Life with MS: Workflows for High Throughput Pesticide Analysis by MS/MS in Challenging Matrices such as Spices and Tobacco

This exclusive Shimadzu Food Safety Webinar will provide an in-depth know-how about the various mass spectrometry (MS/MS) workflows that are needed to conduct high throughput pesticide analysis in challenging matrices. You will learn about the latest state-of-the-art technologies that mass spec leaders are using globally to deal with pesticide analysis in difficult matrices such as spices and tobacco. This webinar will be useful for anyone who is keen to learn about the latest advanced MS/MS technologies and will be particularly interesting for those who have faced difficulties while using challenging matrices.

 

Supporting Food Sustainability in Singapore

In this webinar, besides showcasing Shimadzu workflow solutions for food safety and production, we are honoured to have two distinguished guest speakers - Prof William Chen (Director, NTU Food Science & Technology Programme | Nanyang Technological University ) and Dr Toh Mingzhan (Research Fellow, Fermentation and Flavour Research Group, NUS) to discuss their contribution to the 30 x 30 initiative.

 

Taste Your Food, Not The Container: Off-Flavor Identification from Food Contact Material using Mass Spec

In celebration of our “50th anniversary of Mass Spectrometry”, we are pleased to introduce the Mass Discussion Series focusing of the innovative uses of Shimadzu's mass spectrometry instrument. For this edition, we are so glad to invite Prof. Erich Leitner from Graz University to share his work on off-flavour compound analysis. Off-flavors are not only give taints to food , but may also have an impact on human health. Generally, off-flavors are in trace amounts leaching from food packaging and/or food contact materials. In food safety market, determination of off-flavors and its concentration are essential in food production process, formulating conditions and also quality control. Join this Mass Discussion as Prof. Erich Leitner shares how his lab uses GC/GCMS to identify off-flavors from food contact materials. 

 

The Importance of Ultra Fast Mass Spectrometry for the Analysis of Chemical Hazards in Food & Beverages

Separation Science, in collaboration with Shimadzu,  offers an on-demand webinar and accompanying webinar companion that highlight the importance of ultra fast mass spectrometry for the analysis of chemical hazards in food and beverages. This is discussed in the context of the regulatory requirements for the analysis of contaminants in foods and a general overview of chemical hazards in foods.

 

Forensics Webinars

 

NIST Tools for Confidently Distinguishing Between Hemp and Marijuana

This webinar will focus on the analytical methods and procedures being developed at NIST for accurately measuring cannabinoids (THC, THCA, CBD, etc.) in Cannabis samples and the solutions provided by Shimadzu Scientific Instruments.

 

Systematic analysis of commercial e-liquids: The evolution of GRAS to Inhaled Toxins

Electronic cigarettes (e-cigs) were originally developed as an alternate method for nicotine delivery, and the e-liquids consist of a range of humectant formulations, pharmacologically active ingredients, flavoring chemicals, volatiles, preservative chemicals, and other “enhancing” chemicals.  E-cigs have also been adopted for drugs  other than nicotine (DOTN), including cannabidiol (CBD) and tetrahydrocannabinol (THC). E-liquid manufacturers use chemicals that are generally regarded as safe (GRAS) for oral consumption, but formulations have not been heavily scrutinized by regulatory agencies. As such, e-liquid formulations have evolved as a result of vaping preferences, public health sentiment, and looming regulations.  The chemical composition of e-liquids has been evaluated since 2015, to include humectant formulations, pharmacologically active ingredients, flavoring chemicals, volatiles, preservative chemicals, and other “enhancements”, using TOF MS, HS-GC-FID, GC-MS, and LC-MS/MS. The e-cig industry has provided an aura of safety for consumers. However, the recent EVALI epidemic exposed the toxic nature of vaping while the e-cig industry has facilitated the public consumption of recreational drugs and the abuse of these substances by providing efficient drug delivery devices.  

 

Thermal Desorption GCMS: Supporting Your Arson Analysis

Join us for our first Forensics Webinar! We will be covering the rapidly growing field of Arson as it pertains to TD-GCMS. Come and learn everything you need to know regarding Arson, and Fire Debris and how Shimadzu GCMS paired with thermal desorption will burn through the competition!

Thermal Desorption Webinar 

 

Using MRM/Product Ion Scan Mode in GC-MS/MS to Perform Detection and Differentiation of Synthetic Cannabinoids

Forensic chemists face the challenge of identifying new psychoactive substances (NPS), whereby the general structures of controlled drugs are modified to evade legislative banning. Hence, a plethora of synthetic cathinones and cannabinoids has been available to the public, causing a global social problem. It is therefore crucial that analytical methods are developed for identifying and differentiating new analogues of synthetic drug substances, to prevent potential trading and abuse. Additionally, drug legislation is made more challenging with the use of synthetic cannabinoid containing products, typically marketed as “herbal mixtures”, which consists of analogues of synthetic cannabinoids. In this study, simultaneous multi-reaction monitoring (MRM) and product ion scan (PIS) acquisition methods have been developed for detection and differentiation of isomeric synthetic cannabinoids.

Synthetic Cannabinoids Webinar 

 
 

Life Science Webinars

Applications of ICP-MS in Bioanalysis and the Life Sciences

Inductively coupled plasma mass spectrometry (ICP-MS) is an analytical technique that can be used to measure elements at trace levels in a large variety of biological and environmental samples (e.g., fluids, tissues, seeds, soil, water). Although older techniques such as atomic absorption and atomic emission are still in use by some laboratories, there has been a slow shift toward ICP-MS, particularly in the last decade. From a laboratory perspective, the most important advantage of ICP-MS is the capability to accurately measure trace levels of a wide range of elements simultaneously. Coupled with short analysis time and straightforward sample preparation, this analytical technique offers very high sample throughput in the laboratory. Nutrient levels of chloride, copper, iodine, manganese, iron, selenium, and zinc can be measured in soil, water, plants, as well as human and animal samples. At the same time, toxic levels of metals like arsenic, aluminum, barium, chromium, cadmium, mercury, lead, and nickel can easily be detected and measured quantitatively. This is important in clinical laboratories, environmental research and risk assessments, human and animal health and nutrition, pharmaceutical research and development as well as manufacturing (cGMP), soil and plant health and nutrition, microbiome research, and biopesticide research and development, to name a few.

 

Dissecting the impact of gut microbiome on human health by mass spectrometry-based metabolomics

In this presentation, we will describe results of new studiesemploying a combination of untargeted and targeted metabolomic analyses and functional studies to discover and characterize a new gut microbiota dependent pathway mechanistically linked to the development of cardiovascular disease. Using an initial Learning Cohort of fasting plasma samples from subjects undergoing elective diagnostic cardiac evaluations (n=1,162), analytes whose levels appeared to be associated with incident cardiovascular disease (CVD) risks were identified. Following structural characterization and validation using an independent Validation Cohort (n=4,000) with stable isotope dilution LC/MS/MS analyses, a gut microbiota dependent metabolite was confirmed, and then in animal model studies shown to recapitulate CVD relevant phenotypes in vivo. Microbial bioinformatics studies, genetic engineering (both gain and loss of function) and microbiota transplantation studies confirm a mechanistic link with CVD pathogenesis. And genetic and pharmacological functional studies in rodent models confirmed that the new metabolites interacts with specific GPCRs functionally linked to numerous cardiovascular phenotypes and disorders. The presentation will thus further describe how gut microbiota are mechanistically linked to cardiovascular disease susceptibility, and represent a novel potential therapeutic target for the treatment and prevention of disease.

 

Role of LC-MS in Glycoscience Research

Nitrosamine compounds are classified as probable human carcinogens by the International Agency for Research on Cancer (IARC). Ever since the first U.S. Food and Drug Administration (FDA) notification in June 2018 about levels of these impurities in pharmaceutical API, they have been a reason of continuous discussion globally for analytical scientist, patients and regulators. After June 2018, the number of recalls and 483’s have been on a rise for not only angiostenin II receptor blockers (-ARB, also called as sartans) but also for other products like Ranitidine, Metformin etc. FDA, European Medicine Agency (EMA) and International Council for Harmonisation (ICH) have constantly set and update the guidelines in measuring impurities in pharmaceutical products. Holistic solution to measurement of nitrosamines need both GC-MS/MS and LC-MS/MS technologies.

 
 

Materials/Automotive Webinars

Applications of Py-GC/MS in the Tire Industry

Passenger and commercial vehicle tires are a complex materials technology that may include ten or more distinct layered rubber compounds each formulated to provide different physical and chemical properties based on application and end use.  These compounds are engineered to meet specific metrics related to weight, rolling resistance, and wet traction so as to comply with strict fuel economy and road safety regulations.  Therefore, information obtained for the purposes of reverse engineering and materials analysis is of great value to tire chemists especially in the case of failure investigation. Each rubber material is composed of numerous chemical components such as small molecular compounds (plasticizer oils, anti-degradants, and curatives), oligomers and polymers (reinforcing resins, rubber, and rubber blends), and inorganic fillers (carbon black, silica, clay, etc.).  Because these materials are complex and generally vulcanized analysis can be time consuming and difficult.  Py-GC/MS is a simple and effective method to quickly break down materials for whole sample analysis.  This presentation examines the use of double shot Py-GC/MS in the tire industry for materials characterization and formula reconstruction as compared to traditional methods.

 

Common Standards for Mechanical Testing of Composites

​Fiber reinforced composites are increasingly being used in aerospace, automotive, and industrial applications to build lightweight, high-strength components and structures. Because of their high stiffness and anisotropic properties, a range of demanding tests are required to characterize their mechanical properties. This webinar will give a basic overview of the categories of mechanical testing for composite materials and provide some examples of common test methods and equipment requirements.

 

EPMA: A Revolutionary Approach to Micro-Analysis

Recently, there is an increased demand for surface observation & analysis of elemental distribution on sample surfaces, particularly for metals where it can be used for failure analyses. Being the most effective non-destructive technique for qualitative and quantitative elemental analysis, Shimadzu would like to introduce the Electron Probe Micro-Analyzer (EPMA) as a precise & accurate technique for surface characterization.

 

Expanding Material Characterization Capabilities Using Pyrolysis GCMS

Have you ever wanted an alternate sample introduction method?  Maybe the sample of interest needs to be hotter than a standard inlet will reach.  Pyrolysis is a sample introduction technique that uses elevated temperatures to break down organic materials.  The starting samples can be anything from liquids to solids from many different application areas.  Attend to get your questions answered by the experts.

Material Characterization Capabilities Using Pyrolysis Webinar 

 

Introduction to Light Emission Spectroscopy, with a focus on Fluorescence: Theory and Materials Characterization Applications

This webcast will consist of two parts. Part 1 will start off with a basic introduction to luminescence terminology and electronic theory. Particular attention will be given to photoluminescence, both fluorescence and phosphorescence. Part 2 will discuss several important materials characterization applications.

 

Latest Development in X-Ray Photoelectron Spectroscopy (XPS) Technology

Over the past few decades, the widespread utility and applicability of X-ray photoelectron spectroscopy (XPS) in research and development has made it the most popular and widely used technique of surface analysis. Our latest generation spectrometer, the AXIS Supra+, combines market leading spectroscopic and imaging capabilities with automation to ensure high sample throughput and ease of use. State-of-the-art performance including fast, high spatial resolution XPS imaging reveals the lateral distribution of surface chemistry and aids further characterisation with selected area analysis. We demonstrate the capabilities of the AXIS Supra+ and the technique of XPS in answering materials characterisation questions in application areas such as thin-films, biomaterials and Li-ion batteries.

 

Optical and dielectric properties of novel electronic materials using Shimadzu UV-3600 Plus

We are interested in the growth of new materials and investigate physical properties affected by size, chemical doping, interface, heterostructure, and external tuning parameters (light, magnetic field, etc.). We are particularly interested in understanding the optical and dielectric properties of novel electronic materials that are fabricated in our lab in thin film form. Since the discovery of graphene, Transition metal dichalcogenides (TMDs) have merged as one of the most exciting systems to investigate properties at the nanoscale.  In our lab, we have developed few-layer large-area MoS2 thin-films using a PVD-CVD growth process that can produce films with tunable properties. For this talk, I will specifically focus on their broadband dielectric properties measured using Shimadzu UV3600 Plus.   Next, I will discuss our work on the influence finite-size in Topological insulator Bi2Se3 thin-films. Through a combination of quantum confinement and Burstein-Moss effect, we discovered a large optical blue-shift in Bi2Se3 as it approaches the 2D limit.

 

Plastic Films, Fabrics, Nano Particles, and Butterfly Wings: Novel, “Outside the Box”, Uses For UV/Vis/NIR Integrating Spheres

This webcast will consist of two parts. Part 1 will start off with a basic introduction to UV/Vis/NIR integrating spheres. We will then consider samples, such as plastic films and colored Spectralon®, that illustrate how sphere diameter can impact spectral accuracy in both reflectance and scatter transmission measurements. Part 2 will discuss two novel integrating sphere applications within the rapidly growing technology field of nanomaterials.

UV-Vis Webinar 

 

RoHS : Regulatory compliance and it's solutions

Complying with the European Union (EU) or India's directive on Restriction of Hazardous Substances (RoHS) is an ongoing challenge for many companies. Too often, their compliance activities are unnecessarily complicated by a lack of understanding about what the regulation requires, and how to stay compliant when new restricted substances are introduced. Here in this webinar, our expert team will try to explain about the latest regulation, its implications, along with easy testing solutions to stay compliant to avoid any enforcement action.

RoHS Webinar 

 

Test Standards for the Evaluation of Plastic Tensile and Flexural Properties – ASTM D638 and ASTM D790

ASTM D638 and ASTM D790 are two of the most common test methods for the evaluation of plastic tensile and flexural properties. This webinar will provide an overview of the main factors to keep in mind when performing these tests to make sure you are conforming to the standards and getting good results. It will also discuss some similarities and differences with corresponding ISO methods, ISO 527 and 178, and discuss important instrument requirements such as extensometer accuracy and software capabilities.

 

UV/Vis/NIR Spectroscopy in the Arena of Materials Characterization Research and Quality Control: How Instrumental Performance and Accessories Define Success

Instrumental parameters that are crucial to measuring materials characterization samples are stray light, noise, resolution, and scan speed. In this presentation we will address how these inter-related parameters influence measurement success. It is vital that the proper accessory be employed to match the measurement desired. This presentation will address the function of integrating spheres and how they can be used to measure both diffuse reflection and transmission. Also discussed will be the difference between a relative and absolute reflection measurement. Finally, an overview will be given of important accessories related to the materials characterization marketplace.

UV-Vis Materials Characterization Webinar 

 

Pharmaceuticals & Biopharmaceuticals Webinars

Learn more about our Pharmaceutical & Biopharmaceutical Solutions

Affinity Selection-Mass Spectrometry for the Discovery of Pharmacologically Active Natural Products

Although originally invented for high-throughput screening of combinatorial libraries, affinity selection-mass spectrometry (AS-MS) is ideal for the discovery of lead compounds from chemically diverse sources such as botanical, fungal and microbial extracts. Based on binding interactions between macromolecular receptors and ligands of low molecular mass, AS-MS facilitates the affinity isolation of pharmacologically active small molecules from complex mixtures for mass spectrometric characterization and identification. AS-MS requires no radiolabels, no UV or fluorescent chromophores, and is compatible with all classes of receptors, enzymes, incubation buffers, cofactors, and ligands. The most successful types of AS-MS include pulsed ultrafiltration (PUF) AS-MS, size exclusion chromatography (SEC) AS-MS, and magnetic microbead affinity selection screening (MagMASS), which differ mainly in their approaches for separating the ligand-receptor complexes from the non-binding compounds in mixtures. After affinity isolation, the ligand(s) from the mixture are characterized using high resolution UHPLC-MS and tandem mass spectrometry on instruments such as the Shimadzu LCMS-9030 QToF MS.  Based on HRMS elemental composition and tandem mass spectrometric structural data, the identities of the lead compounds are determined through dereplication by searching on-line databases for known natural products and by comparison with standards. For novel natural products, AS-MS provides UHPLC retention times of active compounds for chromatographic isolation and then complete structure determination using a combination of spectroscopic techniques. Advantages of AS-MS over conventional high-throughput screening are speed, reduced consumption of reagents, compatibility with any receptor and ligand, and the ability to discovery allosteric as well as orthosteric ligands to any receptor, whether or not any ligands are already known.

 

Analytical Technologies for COVID-19 Challenges

The COVID-19 pandemic has brought unprecedented challenges for the communities and economies worldwide, causing a profound effect on the lives of billions of people. While government and communities are trying to contain the spread, researchers are aggressively focusing their efforts towards finding a treatment and/or vaccine. Science is more important now than ever before. This webinar will feature the current analytical technologies and solutions that Shimadzu is committed to provide – such as analytical techniques for drug testing and vaccine research, production and testing of sanitizers and personal protective equipment and analysis of medical sewage waste.

 

Bioassay and Immunogenicity: A Perspective

Bioassay development is a complex process where analysts have to understand biological effect/mode of action of the drug in question and evaluate its immunogenicity. The method selected should be reliable, sensitive, and reproducible and should minimize errors due to biological variation and methodology. Join this session as Dr Dadke shares his expertise on bioassay development and describe the several potential candidates to evaluate immunogenicity of pharmaceutical drugs.

 

Bioprocess Challenges and Learnings

In Biopharmaceutical Manufacturing, the process is the product, and improving upstream processes alone is not enough, downstream damage control is crucial too. In this talk, Dr. Tiwari talks about the challenges in Bioprocess Manufacturing, which occur due to variabilities in the process. Variabilities can arise in the cell culture process as well as the purification process, and need to be monitored, assessed and controlled. Dr. Tiwari highlights the need and importance of in-process analysis of cell culture spent media by LC-MS/MS, with a case study on Cell Culture Profiling using Shimadzu LCMS-8060, which enables simultaneous monitoring of culture medium components. Based on the study on Cell Culture profiling, the media feed was optimized and a robust process control was established. This talk also covers the strategies which can be employed for robust manufacturing of a biosimilar, including process design for control of variability and the use of predictive modelling.

 

Characterization of Protein Aggregation in Therapeutic Peptides and Monoclonal Antibodies

Protein Aggregation, sometimes referred to as non-native aggregation, is one of the most challenging issues during biopharmaceutical product manufacturing, storage, shipping and administration. There has been increasing evidence of increased immunogenicity due to protein aggregation, hence it is essential to characterize and quantify aggregates in order to develop safe and stable biopharmaceutical products. In this talk, Dr. Jain discusses about the types, causes and mechanism of protein aggregation, and the need to characterize aggregates effectively. The various analytical techniques which can be utilized to characterize protein aggregates, and the basis of method selection, have also been highlighted, with an emphasis on Size-Exclusion Chromatography, Dynamic Light Scattering and Analytical Ultracentrifugation.

 

Development and Application of Alternative Ion-Pairing LC-MS/MS Method in Bioanalysis

Ion-Pairing Reversed-Phase Chromatography is a type of column chromatography in which ions in solution can be ‘paired’ or neutralised and separated as an ion pair on a reversed-phase column. Ion pairing reagents can greatly help with problematic chromatography, but any added ion pairing reagents into mobile phases also lead to signal suppression in LC-MS/MS analysis or diminished analytical column performance. In order to overcome these limits, an alternative ion-pairing LC-MS/MS bioanalysis method was successfully developed using Shimadzu LCMS-8060 in two projects. Not like the traditional ion- pairing LC-MS/MS analysis method, the ion pair reagent was not added to the mobile phase, but adding into the sample extract prior to LC-MS/MS analysis. This webinar will introduce 2 Application News for the quantitation of polymyxin B1, B2, B3 and Ile-B1 in human plasma and the bioanalysis of catecholamines including tyrosine, L-DOPA, dopamine and norepinephrine in cell culture samples.

 

Digital Transformation of Laboratory Workspace – Enhancing Workflow with Analytical Intelligence

As the world grapples with COVID-19 pandemic and plans for the aftermath, digitalization of laboratory workspace has become more urgent than ever before. In the future, most scientists will be telecommuting - away from the laboratory – for data analysis and reporting. Time spent in the laboratory itself will be solely for the purpose of analysing samples and pushing data into a secure database to be retrieved remotely. In this 45-min webinar, we will be discussing Shimadzu’s Informatics solutions – how different workflow solutions will facilitate the digitalization of your laboratory workspace by connectng your laboratory instruments, saving the data as well as allowing remote access and control for the users.

 

EDX: A Fast & Simple Technique for Pharmaceutical Elemental Analysis

AA or ICP-OES/MS is often viewed as the golden standard to analyze elements during the pharmaceutical manufacturing process, from drug discovery to the QA/QC of final formulations. While extremely accurate, these techniques have the downside of requiring the sample to be in liquid form when analyzing, resulting in a very arduous sample-preparation process and long analysis time. In this seminar, we would introduce Energy-Dispersive X-Ray Fluoroscopy (EDX) as an alternative technique to perform elemental analysis that requires little sample preparation, is easy to use and can provide results quickly; and how it could be used in various areas of the pharmaceutical industry.

 

EPMA: A Revolutionary Approach to Micro-Analysis

Recently, there is an increased demand for surface observation & analysis of elemental distribution on sample surfaces, particularly for metals where it can be used for failure analyses. Being the most effective non-destructive technique for qualitative and quantitative elemental analysis, Shimadzu would like to introduce the Electron Probe Micro-Analyzer (EPMA) as a precise & accurate technique for surface characterization.

 

Introduction to Extractables and Leachables Study

Recently there is an increasing demand for testing the pharmaceutical product to assess the quality of the packaging and storage materials. These can be a potential source for introduction of a variety of unwanted chemical compounds into the pharmaceutical products leading to health hazards in the patient. Extractable and Leachable study is a tool to screen, identify, and use the best quality packaging material so as to minimize the leaching of the unwanted chemicals into the pharmaceutical product. In this 33 minutes webinar, we will discuss the basic concepts of Extractable and leachable study and try to understand the preliminary workflow for the same. 

 

LCMS-9030 Q-TOF for peptide mapping and structural characterization of mAb biosimilars

Therapeutic monoclonal antibody (mAb) biosimilars are booming in Asia and across the world, as well as faces significant challenges in quality control. Peptide mapping plays a critical role in structure characterization of antibody drugs. This webinar will introduce 4 Application News for structure characterization of bevacizumab biosimilar using LCMS-9030 Q-TOF mass spectrometry, including peptide mapping, C-terminal sequencing, disulfide bond analysis, and N-glycan analysis.

 

New Nexera Series, the First AI Enabled and IoT Driven LC

As one of the most prominent innovators in LC technology, Shimadzu has set the New Benchmark in the LC innovation by developing the very first AI-enabled LC system, which allows Chemists to spend less time operating, and handling the instrument, as the instrument with its in-built Analytical Intelligence algorithm enables the system of performing automation workflow. The ultimate objective is to achieve minimized system downtime, optimize efficiency & maximize productivity, through the New Benchmarks in Intelligence, Efficiency and Design.

New Nexera Series, the First AI Enabled and IoT Driven LC Webinar 

 

Panel Discussion: Confidently Analyse Nitrosamine Impurities by GC-MS/MS & LC-MS/MS

Nitrosamine compounds are classified as probable human carcinogens by the International Agency for Research on Cancer (IARC). Ever since the first U.S. Food and Drug Administration (FDA) notification in June 2018 about levels of these impurities in pharmaceutical API, they have been a reason of continuous discussion globally for analytical scientist, patients and regulators. After June 2018, the number of recalls and 483’s have been on a rise for not only angiostenin II receptor blockers (-ARB, also called as sartans) but also for other products like Ranitidine, Metformin etc. FDA, European Medicine Agency (EMA) and International Council for Harmonisation (ICH) have constantly set and update the guidelines in measuring impurities in pharmaceutical products. Holistic solution to measurement of nitrosamines need both GC-MS/MS and LC-MS/MS technologies.

 

Pharma solutions by GC-MS/MS for Genotoxic Impurities

The following webinar talks about introduction to Genotoxic impurities, current regulations, Shimadzu solution with respect to method development workflow for GTI’s & well-developed applications for quantitation of GTI’s emphasising more on Nitrosamine quantitation in Valsartan & Metformin along with few other applications. It also discusses Shimadzu’s GCMS configurations and accessories as a complete solution for Pharmaceutical analysis. 

 

Streamline and Optimise your Analytical Workflow for Vaccine Testing

Vaccines are biological products used for the prevention or treatment of human diseases . They are made from immunogenic biological materials such as microorganisms, protein, polysaccharides and nucleic acids. Vaccines are produced using either traditional methods or modern biological technologies like genetic engineering. In the current COVID-19 pandemic situation, scientists and researchers around the world are not only trying to discover the COVID-19 cures, but also aiming to develop the vaccines to prevent the spread of the disease. In the webinar, we will share with you how Shimadzu analytical tools can help with the development and quality control of different types of vaccines products.

 

The Next Industry Standard GC: Nexis GC-2030

This webinar introduces Shimadzu's Next Industry Standard GC, Nexis GC-2030. The Shimadzu's premier gas chromatograph offers a modern approach to a classic chromatographic technique. Designed with the user in mind, new innovative features, exceptional performance and high-throughput capabilities will elevate your lab to the next level.

 

Toolkit for Treasure Hunt - Drug Discovery Made Easy

The hunt for novel drug candidate is a tedious and time-consuming process. A good workflow efficiency, from start of chemistry to purification to structural elucidation should streamline the discovery process and increase the success rate of developing novel candidate compound. In this Mass Discussion, Dr. Ramesh Appadurai from Syngene International and Pottayil G Sasikumar from Aurigene Discovery Technologies will share their experience in running successful R&D pipeline with the latest technology advancement. Let us also take a brief glimpse of Shimadzu's innovative drug discovery solutions which are designed to provide comprehensive and holistic workflow solution, ensuring faster result generation and maximizing ROI

 

Validation of Quantitative Method for Determination of Elemental Impurities in Pharmaceutical Products Following USP 232/233 on ICPMS-2030

24 targeted elemental impurities in three drug products were determined following new USP chapters <232>/<233> using Shimadzu ICPMS-2030. The method was evaluated and validated according to the procedures defined by USP <233> and combined with microwave digestion for sample preparation. Good calibration linearity, repeatability, stability and specificity were achieved for all 24 impurities. Low LODs and LOQs were obtained as compared to the target limits from USP <232>. The ICP-MS method applying universal He collision mode provides a high throughput method for routine elemental impurity analysis in pharmaceutical products.

 

For Research Use Only. Not for use in diagnostic procedures.

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