Liquid Chromatography / Mass Spectrometry (LC-MS) Webinars
Direct Probe Ionization Mass Spectrometry (DPiMS) for High Throughput Analysis
Evolution of mass spectrometry (MS) hardware, especially ionization method, has drastically changed the landscape of MS applications. Direct Probe Ionization Mass Spectrometer (DPiMS) has the potential to pioneer new types of applications with the new ionization interface. The technique successfully incorporated the best of both worlds; high ionization efficiency of ESI and simplicity of MALDI. This was achieved by using an ultrafine needle to sample an extremely small volume of sample on its surface and subsequently applying high voltage to the needle to imitate an ESI probe. DPiMS is characterized by the microscopic sampling volume and high sensitivity for the amount sampled at a low ng/mL concentration range. For this, DPiMS can be a robust solution for the routine analysis of high-complexity matrices, such as plasma or food extract, as contamination of MS hardware can be perfectly mitigated. Moreover, direct sampling from solid samples causing minimal destruction might enable new applications such as real-time analysis of live tissues or cells.
LCMS-9030 Q-TOF for peptide mapping and structural characterization of mAb biosimilars
Therapeutic monoclonal antibody (mAb) biosimilars are booming in Asia and across the world, as well as faces significant challenges in quality control. Peptide mapping plays a critical role in structure characterization of antibody drugs. This webinar will introduce 4 Application News for structure characterization of bevacizumab biosimilar using LCMS-9030 Q-TOF mass spectrometry, including peptide mapping, C-terminal sequencing, disulfide bond analysis, and N-glycan analysis.
LC-MS(MS) Method Development: HPLC vs LC-MS(MS) Method Development
This webinar is on LC/MS/MS Method Development and is designed for newcomers to LCMS. This presentation will cover: Some introspection, How you view your analytical system, MS and MS/MS 101, Anatomy of an LC system, Is mass spec 'just a detector'?, Anatomy of an LC-MS(MS) system, Low vs High resolution method development, Advantages and disadvantages of LC-MS(MS), HPLC vs LC-MS(MS) method development
LC-MS/MS methods for vitamin B and D analyses as per AOAC methods in infant and adult formulae
Vitamin B and D are important micronutrients to maintain good health. They are often fortified in various foods such as infant and adult formulae for added health benefits. Over the years, there are many AOAC methods dedicated to the analyses of different vitamin B and vitamin D compounds in infant and adult formulae. In recent years, many AOAC methods use LC-MS/MS to analyse both these vitamins. In this webinar, I will discuss about the different AOAC methods and the sample preparations in the analysis of vitamin B and D. I will also share some of the application development works done closely following AOAC methods using Shimadzu LC-MS/MS.
Panel Discussion: Confidently Analyse Nitrosamine Impurities by GC-MS/MS & LC-MS/MS
Nitrosamine compounds are classified as probable human carcinogens by the International Agency for Research on Cancer (IARC). Ever since the first U.S. Food and Drug Administration (FDA) notification in June 2018 about levels of these impurities in pharmaceutical API, they have been a reason of continuous discussion globally for analytical scientist, patients and regulators. After June 2018, the number of recalls and 483’s have been on a rise for not only angiostenin II receptor blockers (-ARB, also called as sartans) but also for other products like Ranitidine, Metformin etc. FDA, European Medicine Agency (EMA) and International Council for Harmonisation (ICH) have constantly set and update the guidelines in measuring impurities in pharmaceutical products. Holistic solution to measurement of nitrosamines need both GC-MS/MS and LC-MS/MS technologies.
Panel discussion: the pros and pros of HRMS implementation in quantitative routines
This free panel discussion welcomes the expert panelists to provide insights into the use of HRMS across a variety of fields, namely food safety, forensics and clinical research. The discussion will feature how HRMS compares with TQMS, main drivers for implementation, common challenges and opinions on what the future holds.
HRMS Discussion Webinar
Shimadzu ‘Reboots’ LC-MS/MS triple quadrupole technologies and capabilities at ASMS 2020; we have something new to talk about…
This webinar will walk through how the new IonFocus system can make a real difference to LC-MS/MS workflows and headline new software capabilities in making data review easier and quicker. Find out how this next step in LC-MS/MS could make a real difference to your lab.
Shimadzu ‘Reboots’ LC-MS/MS Triple Quadrupole Technologies and Capabilities Webinar
Understand the rationale behind the Q-TOF LC/MS that stably sustains sub-ppm mass accuracy.
The webinar describes various metrics that are relevant to statistical interpretation of MMA, which explain why mass resolution of 30,000 is more than sufficient for mass measurement at sub-ppm accuracy. Using the Shimadzu LCMS-9030 quadrupole time-of-flight MS, the rationale and strength of instrument stability for consistently achieving sub-ppm MMA has been demonstrated in small molecules.
Q-TOF LCMS Webinar