LCMS-TQ RX Series - Features

Triple Quadrupole LC-MS/MS


LCMS-TQ RX Series CoreSpray Technology  

 LCMS CoreSpray Technology
Heated ESI Probe
Heated ESI Probe
CoreSpray Technology
CoreSpray Technology


CoreSpray (1)

Corespray Technology


Enhanced Ionization Performance

CoreSpray, a newly developed gas delivery system, improves performance and uniformity of nebulization with higher flows and better heat transfer.

  • Heated ESI Probe (2)

    Each RX Series instrument is equipped with a heat-assisted electrospray ionization probe. The resulting highly-efficient desolvation process promotes the ionization of a wide range of targeted compounds.

  • IonFocus™ Unit (3)

    All models are now equipped with Shimadzu’s unique IonFocus™ unit. The focusing electrode efficiently delivers ions into the mass spectrometer while minimizing matrix interference.



Ultrafast Sensitivity and Performance 

Shimadzu's RX Series expands the capability and productivity of the triple quadrupole mass spectrometer with performance that can be relied upon. The RX Series has been designed to generate a highly focused ion beam from the ion source to the detector bringing together our advanced ion guide and collision cell technologies. The result is higher data quality which impacts every LC-MS/MS assay.




Peak Area Stability in Matrix: 20,000 Continuous Injections

CoreSpray technology applied to the repeated analysis of pesticide residues within a black tea matrix has demonstrated outstanding robustness, achieving a %RSD of less than 3.5% over 20,000 injections.. This data was produced without the use of internal standards and without diverting the polar black tea matrix to waste at the start of each run, underscoring the reliability and ruggedness of the RX series.

Peak Area Stability in Matrix: 20,000 Continuous Injections




Maximizing Overall Workflow Efficiency

  • Intelligent tools to optimize the efficiency of your workflow, boost productivity and improve data quality.

  • Maximizing Overall Workflow Efficiency



Instrument Check Analytical IntelligenxcePerformance Concierge

PERFORMANCE CONCIERGE makes tuning a mass spectrometer easier than ever before. A tuning standard is automatically introduced into the instrument to verify parameters, including mass accuracy, resolution, and signal strength. Based on these checks, tuning may be automatically initiated to ensure optimal performance. Should the criteria not be met, PERFORMANCE CONCIERGE will diagnose the issue and alert the operator of required maintenance, thereby maximizing uptime.

LCMS Instrument Check



Optimization of Acquisition Conditions

Automates MRM optimization to create high sensitivity quantitative LC-MS/MS methods. LabSolutions Connect MRM not only optimizes target component MRM transitions and collision energies but also maximizes the response for on column analysis. All optimized acquisition parameters are stored in a data base helping to accelerate both method development and routine analysis.


MRM Optimization of Acquisition Conditions




Startup Analytical Intelligenxce

Integrated intelligence on the Nexera LC series that allows you to increase column life-times and reduce consumables by enabling automated column equilibration for flow rates and temperature.




Data Analysis 

Peak Integration Analytical Intelligenxce

Get expert-level results in less time with our AI-powered peak integration algorithm. This user-friendly tool requires no user input, eliminating the need for complex parameter configuration, while streamlining your workflow and data analysis .



LCMS Peakintelligence



  • Pesticides
  • PeakIntelligence for LCMS was applied to the analysis of a panel of pesticides in a residue screening study highlighting consistent peak integration at low S/N or with overlapping components.



  • Peakintelligece for LCMS
  • PeakIntelligence for LCMS is an AI-driven algorithm for component detection and peak integration without the need for user screening parameters or input. PeakIntelligence for LCMS processes results with higher consistency in peak integration and reduces the time-consuming impact of manual review to achieve more accurate and reproducible peak processing.


Reviewing Data and Reporting Results

LabSolutions Insight streamlines data review for mass spectrometry labs by seamlessly integrating quantitative analysis and screening. This powerful software prioritizes your attention with "review by exception" functionality. User-defined criteria automatically flag outliers, allowing you to focus on exceptions that require further investigation. This reduces the risk of false positives/negatives and expedites reporting, boosting lab efficiency and productivity.


LabSolutions Insight



Easy LCMS Maintenance Shortens Instrument Downtime

The RX Series keeps the same user-friendly maintenance as its predecessors. Changing the ESI capillary and the desolvation line (DL), which transports ions into the vacuum region, are designed for quick and effortless replacement without breaking vacuum helping to reduce time spent on maintenance and increase instrument uptime.

Easy LCMS Maintenance - DL Replacement



Highly Energy Efficient

Ecology Mode


The LCMS-TQ RX Series prioritizes environmental responsibility with its built-in ecology mode. This mode monitors system usage and automatically shuts down the instrument when idle for extended periods, reducing electricity consumption by an impressive 31%. Additionally, powering down peripheral LC-MS/MS equipment during non-analysis periods further minimizes energy use. These features contribute significantly to lowering operating costs and CO2 emissions while supporting the pursuit of a carbon-neutral future.

Reduced Waste to the Environment

The new oil-free addition to our rotary pump line eliminates the labor of oil changes, reduces overall oil consumption, and produces less environmental waste. Additionally, the Performance Concierge and ecology mode minimize solvent and power consumption, reducing environmental impact.

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