Prominence Inert LC System

Ideal for Size Exclusion Chromatography of Biopolymers

Ideal for Size Exclusion Chromatography of Biopolymers

Inert LC System

A new inert LC system is now part of Prominence series. Featuring the same high reliability, robustness, and expandability as the Prominence series, this system is ideal for the analysis of biopolymers such as antibody drugs.

Monoclonal Antibody
Bromate Analysis System

Stable Data

The Prominence inert LC system employs non-metallic materials such as PEEK resin in the liquid contact parts for the mobile phase and sample solution. It not only enables high concentration salts and acids to be used in the mobile phase, but it also suppresses the adsorption of samples with high affinity to metals.

prominence inert lc system diagram

The newly designed LC-20Ai solvent delivery unit offers highly reproducible analyses due to an extremely accurate liquid delivery capability.

corrosion resistance test results with parts in contact with liquids

Size Exclusion Chromatography

In size exclusion chromatography (SEC) analysis of biomolecules, a mobile phase containing halide salts such as sodium chloride is delivered to an SEC column in isocratic mode, the molecular weights are determined and aggregates such as dimers analyzed. In order to obtain stable data in SEC, a highly accurate solvent delivery capability is required.

size exclusion chromatography

Ion Exchange Chromatography

In ion exchange chromatography (IEX) analysis of biomolecules, a mobile phase containing halide salts is delivered to an IEX column in gradient mode and charge variants separated and detected. In order to obtain stable data in IEX, a highly accurate gradient delivery capability is required.

charge variant analysis by cation exchange chromatography

Note: Monoclonal antibodies were provided by Assistant Professor Takashi Matsuzaki of the Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine.

For Research Use Only. Not for use in diagnostic procedures.

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