SIL-30ACFV Flow Vial Autosampler for Dissolution
The Nexera series SIL-30ACFV autosampler is a unique flow vial autosampler for use with 3rd party dissolution systems.
What is dissolution?
The effectiveness of a drug’s dosage form relies on the drug dissolving in the fluids of the GI tract prior to absorption in the body. Dissolution is a standardized method for measuring the rate of drug release from a dosage form. The typical technique for dissolution is the paddle/basket method – a paddle stirs a solution to dissolve a drug dosage form and the solution is then tested periodically to determine when it has completely dissolved. Dissolution analyses involve either UV spectroscopy or HPLC with UV detection. Manual sample collection limits lab productivity.
Ref: Performance Evaluation by Dissolution Testing System
Evaluation of tablet dissolution using fully automated dissolution system coupled with UHPLC (P21-11)
Takuya Murayama1, Mina Yamada2, Toshi Kajiro1, Motomu Ohara1, Yosuke Iwata3, Taichi Tomono3, Tadayuki Yamaguchi3, Yasunori Shimizu4, Akiyoshi Banba4, Koichiro Sumida4
1 Analytical & Quality Evaluation Research Laboratories Daiichi Sakyo Co., Ltd,
2 Formulation Technology Research Laboratories Daiichi Sankyo Co., Ltd.,
3 Shimadzu Corporation,
4 Dainippon Seiki Co., Ltd.