Nexera XR
Ultra High Performance Liquid Chromatograph

Nexera XR
The Shimadzu Nexera XR ultra high-performance liquid chromatograph (UHPLC) represents an increase in efficiency over the Prominence system, allowing customers to pursue high-speed, high-resolution chromatography.

The Nexera XR system provides accurate and reproducible results and has proven to be an indispensable tool for laboratories in a variety industries including pharmaceuticals, biochemistry, chemistry, environmental, and food science.

Take full advantage of a HPLC/UHPLC system with the Nexera XR - the system for your chromatographic needs.

  • Method Scouting - Switch between 8 mobile phases, 6 columns for up to 96 method combinations.

  • Increased Throughput – Maximize sample throughput with precision, high-speed injections.

  • Your choice of detection – UV-Vis, Photodiode Array, Refractive Index, Fluorescence, Conductivity, etc.

  • Large Capacity Oven – Can fit up to 300 mm columns, 2 flow control valves, 2 manual injections, and a gradient mixer.

Click the name of a component to view more information. Nexera XR Components Degasser Pump Autosampler System Controller Detector Column Oven
Capable of both HPLC and UHPLC Analysis

Ability for method transfer between standard HPLC and UHPLC (as low as 2 μm particle size columns) systems.

Flow Rates

Solvent Delivery Unit
Unrivaled solvent delivery units

World class pumps with improved performance at micro-flow rates and up to 5 mL/min.

Pulse-free solvent delivery that is essential for high quality data acquisition.

Accurate gradient programs can be achieved by low pressure gradient elution or a binary pump system. An optional quaternary solvent delivery valve can be used for gradient or isocratic elution

Increased Data Sensitivity and Reliability

The Nexera photodiode array detector (SPD-M30A) introduces a capillary type cell which gives higher sensitivity and lower dispersion for superior data.

The detector is temperature controlled to increase baseline stability and reproducibly.

Data Sensitivity

sample capacity
Needle-in-Flow Path Autosampler with Increased Throughput

Flow through the needle reduces sample carryover to an absolute minimum.

The high-performance measuring pump provides precision and accuracy for sample injections of even the smallest volumes (1 µL or less).

Increased sample capacity with full automation and high speed injections (minimum of 10 seconds).

LabSolutions Method Scouting for Method Development System

This system streamlines the process for more efficient and accurate method development by automatically switching between up to 96 combinations of unique separation conditions (with up to 6 columns, 8 mobile phases, and 10 gradient settings).

method scouting diagram

CBM web browsing software screen
CBM Web Browsing

Ability to monitor and control you LC system over a network.

Simultaneous wavelength measurement

Temperature Control Graph
Large Capacity Column Oven with Precision Temperature Control

Oven temperature is calibrated at two different points to ensure a high degree of accuracy.

Large column compartment can comfortably hold up to three 300 mm columns, two flow control valves, two manual injectors, and a gradient mixer.

Hardware Specifications (Limited)

Here are limited specifications for the typical components used in the Nexera XR system.

Detailed specifications are located within the component's pages.

System Controllers
Column Ovens
Degassing Unit 3 or 5 Lines (Volume 400 μL)
Pulsation 0.1 MPa (1.0 mL/min,10 MPa, Water)
Flow rate range 0.0001 to 5 mL/min
Flow rate precision No more than 0.06% RSD or 0.02 min SD, whichever is greater
Gradient type High-pressure / low-pressure mixing gradient
Gradient / concentration precision ±0.5% (specified conditions)
Maximum pressure 66 MPa (0.0001 to 3 mL/min)
44 MPa (3.0001 to 5 mL/min)
Injection method Needle-in-flowpath
Injection volume accuracy ±1% (at 50 μL injectiong, n = 10)
Injection volume range 0.1 to 50 μL (Option: 0.1 to 100 μL)
Injection volume reproducibility RSD: 0.3% maximum (at 10 μL)
Samples capacity Sample plate: 175 (1 mL), 105 (1.5 mL), 50 (4 mL), 2 (MTP/DWP plates)
Control plate: 10 (1.5 mL)
Sample cooler Block cooling/heating, used together with defumidifying function
4 to 40°C
*No sampler cooler included in SIL-20AXR model
Oven Capacity W220 × D95 × H365 mm
Temperature control range Room temperature ± 10 to 85°C, Setting range 4 to 85°C
UV Detector
Wavelength Range 190 to 900 nm (with optional tungsten lamp)
Noise level ±2.5 × 10−6 AU, (250 nm, Specified condition)
Flow cell 12 μL (10 mm), 12 MPa
Option cell High-Sensitivity: 8 μL (10 mm)
Semi-micro: 2.5 μL (5mm)
PDA Detector
Wavelength Range 190 to 800 nm
Noise level ±3 × 10−6 AU, (250 nm, Specified condition)
Flow cell 10 μL (10 mm), 8 MPa
Option cell High-Sensitivity: 8 μL (10 mm)

Easy to use and intuitive data acquisition and analysis software to control your LC or GC systems

Several software packages to find the one that fits your needs; LabSolutions, LabSolutions CS, LabSolutions DB, etc.

Fully compliant with a variety of regulations and guidelines including:
  • CSV, Ministry of Health
  • Labor and Welfare ER/ES guidelines
  • FDA 21 CFR Part 11

LabSolutions Software Screens
Learn more >>
Shimadzu offers the following training classes:

HPLC-101: Shimadzu Modular HPLC Training with PM
HPLC-102: Shimadzu i-Series HPLC Training with PM

Click here to learn more!

Shimadzu has launched its interactive "Virtual Advisor" websites to further enhance customer service.

>> Learn about the Nexera Virtual Advisor.

For Research Use Only. Not for use in diagnostic procedures.