Webinar - A systematic analysis of commercial e-liquids: The evolution of GRAS to Inhaled Toxins

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Title: A systematic analysis of commercial e-liquids: The evolution of GRAS to Inhaled Toxins

Duration: 1 Hour 23 minutes

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Summary

Electronic cigarettes (e-cigs) were originally developed as an alternate method for nicotine delivery, and the e-liquids consist of a range of humectant formulations, pharmacologically active ingredients, flavoring chemicals, volatiles, preservative chemicals, and other “enhancing” chemicals.  E-cigs have also been adopted for drugs  other than nicotine (DOTN), including cannabidiol (CBD) and tetrahydrocannabinol (THC). E-liquid manufacturers use chemicals that are generally regarded as safe (GRAS) for oral consumption, but formulations have not been heavily scrutinized by regulatory agencies. As such, e-liquid formulations have evolved as a result of vaping preferences, public health sentiment, and looming regulations.  The chemical composition of e-liquids has been evaluated since 2015, to include humectant formulations, pharmacologically active ingredients, flavoring chemicals, volatiles, preservative chemicals, and other “enhancements”, using TOF MS, HS-GC-FID, GC-MS, and LC-MS/MS. The e-cig industry has provided an aura of safety for consumers. However, the recent EVALI epidemic exposed the toxic nature of vaping while the e-cig industry has facilitated the public consumption of recreational drugs and the abuse of these substances by providing efficient drug delivery devices.  

Video

For Research Use Only. Not for use in diagnostic procedures.

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