Highly sensitive LC-MS/MS method for the determination of NDMA, NDEA, NDIPA, NMBA, NEIPA and NDBA in Metformin drug substance

Health Sciences Authority (HSA) of Singapore on 4th December 2019 recalled three out of 46 locally marketed Metformin medicines after detecting presence of NDMA “above the internationally acceptable level” and this subject came into mainstream. Subsequently, both the US Food and Drug Administration (FDA) and the European Medicines Agency (EMA) have released regular updated into their investigations into the causes of medicine contamination.

Content Type:
Document Number:
ASMS 2020 - ThP 572
Product Type:
Liquid Chromatography Mass Spectrometry
Pharma & Biopharma, LCMS-8045 Triple Quadrupole Liquid Chromatograph Mass Spectrometer (LC-MS/MS)
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