Highly sensitive analysis of glyphosate, glufosinate and AMPA in the tap water and the beverages by LC-MS/MS without derivatization

Direct analysis of glyphosate, glufosinateand AMPA in the drinking water and the beverages was developed with good recovery factors. Glyphosate and glufosinate are active ingredients in widely used herbicides for broadleaf weeds and grasses. In the EU, the required LLOQ for glyphosate and its metabolite, aminomethylphosphonic acid (AMPA), in water is 0.1 ug/L. A derivatization process with such as FMOC is performed for these compounds in pretreatment since their retention on the reversed phase column are weak due to their hydrophilicity. Aiming to reduce the complex and time-consuming derivatization procedure, we introduce a high-sensitive direct analysis of glyphosate, glufosinate and AMPA without derivatization. Highly sensitive results could be obtained with good recovery factors for the drinking water and the beverages with limited pretreatment procedures such as filtering and dilution.

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Document Number:
ASMS 2020 - WP 163
Product Type:
Liquid Chromatography Mass Spectrometry
Food, Beverages, Environmental, LCMS-8060 Triple Quadrupole Liquid Chromatograph Mass Spectrometer (LC-MS/MS)
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