MALDI-nanochip based Screening of Exosomal Biomarkers: Application to Cancer Diagnostics

We previously demonstrated we could rapidly distinguish fluorouracil resistant cancer sample groups based on protein profiling of extracellular vesicles using a linear benchtop MALDI TOF instrument [1]. The aim of this follow up work is to identify the proteins that are differentially expressed in the different sample groups in order to better understand the disease processes and to support the rapid screening approach developed previously. Here we present the results from this study using a high performance reflectron MS/MS MALDI-TOF platform (Fig. 1) for the comparative proteomic profiling of circulating extracellular vesicles (EV) extracted from plasma samples of patients with colorectal cancer, postoperative colorectal cancer patients, IBD patients and a healthy control group in view of liquid biopsy applications (as a potential application for liquid biopsy oncological diagnosis).

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Document Number:
ASMS 2020 - WP 031
Product Type:
Life Science, MALDI-TOF Mass Spectrometry
Clinical Research, Life Science Solutions, MALDI-7090 TOF-TOF Mass Spectrometer
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