Utilizing U-Shaped Mobility Analyzer (UMA) for High Performance Bio-molecular Analysis

High resolution, wide dynamic range of filter mode and accurate CCS measurement make UMA a powerful analytical device in bio-molecular analysis. Ion mobility spectrometry (IMS) is a useful tool for separating and characterizing ions in gas phase. Recently, HPLC-IMS-MS has been widely accepted as an advanced technique for –omics studies. U-Shaped mobility analyzer (UMA) is a newly established ion mobility spectrometer which has multiple operation modes (filter mode, trap-scan mode and through mode) and high performance, as shown in Fig 1. UMA has reached high resolution of >200 for singly charged ion and ~600 for multiply charged ion. In UMA analysis of proteins, a plenty of protein conformers were resolved at several charge states. In UMA filter-scan mode, low abundant ions have lower limit of detection (LOD) than in trap-scan mode. Collision cross sections (CCS) can be accurately measured by UMA. These features make UMA a powerful analytical device in -omics studies.

Content Type:
Poster
Document Number:
ASMS 2020 - ThP 337
Product Type:
Liquid Chromatography Mass Spectrometry
Keywords:
Life Science Solutions, LCMS-8040 Triple Quadrupole Liquid Chromatograph Mass Spectrometer (LC-MS/MS)
Language:
English
File Name:
ThP337-ASMS-2020-Poster.pdf
File Size:
524kb

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