Multiple Reaction Monitoring (MRM) is the standard method of data acquisition for high sensitivity Triple Quadrupole LC-MS/MS analysis. Each MRM precursor ion and product ion pair represents a specific fragmentation transition for a given molecule. For even more specificity, multiple MRM transitions are often monitored for each analyte. Establishment of accurate MRM transitions requires the analysis of an authentic
standard under a range of voltages to optimize sensitivity. Shimadzu’s LC-MS/MS Method Package for Residual Pesticides Ver. 3 is a data base containing multiple preoptimized MRM transitions for 836 pesticides, including chromatographic conditions. These 836 pesticides represent a combination of several world-wide regulatory lists, including the Japanese Ministry of Health, Labour and Welfare (MHLW) positive list system, Regulation (EC) No 396/2005 of the European Parliament and of the Council, and China's food safety national standards regulations (GB standards). LabSolutions Connect easily creates MRM methods for any of these lists or any combination of analytes.