Quadrupole Time-of-Flight Liquid Chromatograph Mass Spectrometer
Research-grade Q-TOF LCMS. Perform Critical Analysis with Confidence.
The LCMS-9030 quadrupole time-of-flight (Q-TOF) mass spectrometer is a powerful instrument that integrates the world's fastest and most sensitive quadrupole technology with TOF capabilities for accurate mass measurement.
The LCMS-9030 provides superior sensitivity for quantitative and qualitative analysis of samples over a wide concentration range, including ultra-trace compounds. Patented technologies ensure high resolution and excellent mass measurement accuracy (MMA), supporting structure elucidation and identification of unknown compounds. High throughput is achieved with Shimadzu's unique acceleration technologies designed for high-speed data acquisition.
High-Efficiency Quadrupole Technologies
UFaccumulation™ (Pat. US 10020181)
Ion accumulation in the collision cell, synchronized perfectly with short cycles of data acquisition, maximizes sensitivity.
UFgrating™ (Pat. US 9048082)
Shimadzu's world-class manufacturing capability has enabled the ion acceleration electrode to be made with substantial mechanical strength. This grating is able to withstand the high voltages needed for ultrafast ion pulsing.
UF-FlightTube™ (Patent Pending)
Mass accuracy needs mass stability. Shimadzu's temperature-controlled UF-FlightTube requires less frequent calibration, enabling you to run more samples.
iRefTOF™ (Pat. US 8772708, 9490114)
A computationally ideal electrostatic field has become a reality. Meticulously manufactured plate electrodes are stacked to create a reflectron which turns ions with no compromise in resolution or sensitivity.
A Slim, Floor-Standing Design
The simple and compact design conserves valuable laboratory space.
LCMS-9030 Receives an iF DESIGN AWARD 2019
Webinar - Analysis of Monoclonal Antibody (mAb) and Related Biologics by LC and LC-MS Platforms
Monoclonal antibodies (mAbs) are a class of biotherapeutics that are rapidly gaining traction. The higher-order structures of mAbs play a crucial role in determining their efficacy and safety. It is crucial that mAbs are accurately characterized before they can become biotherapeutics. A better understanding of mAbs helps craft better bioprocesses, formulas, and dosages. In this study, a recombinant human IgG NIST mAb reference standard was analyzed using high resolution quadrupole time of flight liquid chromatography-mass spectrometry (QTOF-LCMS). An innovative proteolysis method called nano-surface and molecular-orientation limited proteolysis (nSMOL) selectively cleaves Fab regions of mAbs. Regardless of the type of antibodies scientists use, nSMOL can be used to develop analytical methodologies. Triple quadrupole liquid chromatography-mass spectrometry (TQ-LCMS) permits multiple reaction monitoring (MRM) to determine the level of fragmentation in peptides derived from Fab. Furthermore, a protocol for selecting pharmacokinetically suitable signature peptides was developed using nSMOL and TQ-LCMS.
Understand the rationale behind the Q-TOF LC/MS that stably sustains sub-ppm mass accuracy
High-resolution, accurate-mass (HRAM) mass spectrometers (MS) are a class of MS instrumentation with capability to resolve complex sample matrix and to allow identification of compounds by measuring their accurate masses. In particular, those coupled to liquid chromatograph (HRAM LC/MS) have been used extensively for structural elucidation of unknown compounds primarily in chemical industry (impurity analysis) and biological researches (proteomics, metabolomics, lipidomics), but also increasingly in forensic science, food safety and environmental testing. Given the recent reduction of instrumentational cost, it will not take many more years until HRAM analysis becomes a versatile tool for all industries and researches.
The webinar describes various metrics that are relevant to statistical interpretation of MMA, which explain why mass resolution of 30,000 is more than sufficient for mass measurement at sub-ppm accuracy. Using the Shimadzu LCMS-9030 quadrupole time-of-flight MS, the rationale and strength of instrument stability for consistently achieving sub-ppm MMA has been demonstrated in small molecules.
LCMS-9030 Quadrupole Time-of-Flight Liquid Chromatograph Mass Spectrometer
The LCMS-9030 quadrupole time-of-flight (Q-TOF) mass spectrometer integrates the world' s fastest and most sensitive quadrupole technology with TOF architecture. A product of Shimadzu's engineering DNA, speed and effortless performance enable the LCMS-9030 to address qualitative and quantitative challenges with genuine confidence and ease.
Improving Extractables and Leachables Analysis in Food Contact Materials Using Shimadzu's Q-TOF
Leachables and extractables pose risks to food contact materials. Shimadzu's Q-TOF mass spectrometer provides fast, reliable analysis of these contaminants in food products.
Webinar - Affinity Selection-Mass Spectrometry for the Discovery of Pharmacologically Active Natural Products
LabSolutions Insight Library Screening Data Processing
This video describes the simple steps it takes to easily process QTOF or QQQ data using the library search function within LabSolutions Insight, Shimadzu’s data processing software. Cleary demonstrated is how to load a batch, set up flags, search within a library and report the final result.
News / Events
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Shimadzu at ASMS 2022
Join Shimadzu in Minneapolis for ASMS 2022 - June 5th - 9th
Achieve Effortless High-Speed High-Sensitivity Analysis With New Space-Saving LCMS-2050 Single Quadrupole Mass Spectrometer
Shimadzu Scientific Instruments introduces the LCMS-2050 Liquid Chromatograph Quadrupole Mass Spectrometer that features a significantly reduced size, while providing high speed and high sensitivity analysis. Designed for effortless operation, the LCMS-2050 mass spectrometer combines ease of use as an LC detector with excellent MS capabilities.
iF design award
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