LCMS-8065XE - Features

Revolutionary New Technology Achieves Exceptional Performance

Our latest technologies included in the LCMS-8065XE bring sample analysis to a new level. Through evolution of our UF technologies, ESI probe, and collision cell, we are pushing the boundaries to achieve the highest level of performance.

Exploring the Core of High-Sensitivity Analysis

The newly designed StreamFocus ESI probe enhances UFsensitivity™ analysis by reducing droplet dispersion within the ESI spray. Equipped with a specially engineered low-diffusion nebulizer nozzle, it enables greater ion intake while reducing nebulizer gas consumption—making it particularly well-suited for reducing operational expenses.

The IonFocus unit in the LCMS-8065XE optimizes ion transmission. It solves the common trade-off between contamination reduction and sensitivity loss by using an electrode to focus and direct only target ions into the mass spectrometer, excluding neutral contaminants. This results in high sensitivity, exceptional robustness, and enhanced instrument uptime for reliable, long-term analysis.

New UF Technologies Enable Ultra-Fast Mass Spectrometry Applications

Shimadzu’s triple quadrupole mass spectrometers, powered by a suite of proprietary UF Technologies, have earned widespread acclaim from users across diverse applications. The new LCMS-8065XE incorporates the latest advancements in these technologies, delivering unmatched sensitivity and faster analysis speeds—redefining what’s possible in quantitative mass spectrometry.

UFsweeper™ Ⅳ

Shimadzu's proprietary UFsweeper™ technology—designed to efficiently guide ions through the collision cell without energy loss—has been further refined. The updated collision cell features a larger entrance lens diameter and an increased number of lenses, significantly boosting ion throughput. These improvements result in enhanced ion transmission and greater sensitivity, enabling more precise and reliable quantitative analysis.

Easy Maintenance Shortens Instrument Downtime

Both the desolvation line (DL), which delivers samples to the vacuum section, and the ESI capillary can be replaced quickly and easily. Even the DL can be replaced without breaking vacuum, helping to minimize downtime and maintain laboratory productivity.

Maximizing Overall Workflow Efficiency

Intelligent tools to help your workflow efficiency generating higher productivity and better data quality.

Preparation

Instrument Check

PERFORMANCE CONCIERGE™ makes tuning a mass spectrometer easier than ever before. A tuning standard is automatically introduced into the instrument to verify parameters, including mass accuracy, resolution, and signal strength. Based on these checks, tuning may be automatically initiated to ensure optimal performance. Should the criteria not be met, PERFORMANCE CONCIERGE will diagnose the issue and alert the operator of required maintenance and maximize uptime.

Optimization of Acquisition Conditions

LabSolutions connect MRM automates MRM optimization to create high-sensitivity quantitative LC-MS/MS methods. LabSolutions Connect MRM not only optimizes target component MRM transitions and collision energies but also maximizes the response for on column analysis. All optimized acquisition parameters are stored in a data base helping to accelerate both method development and routine analysis.

Startup

Integrated intelligence on the Nexera LC series that allows you to increase column lifetimes and reduce consumables by enabling automated column equilibration for flow rates and temperature.

Reviewing Data and Reporting Results

LabSolutions Insight accelerates quantitative data review with ‘review by exception', highlighting only results outside user-defined criteria to deliver fast, high-confidence reporting.

Data Analysis

Peak Integration

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This example highlights Peakintelligence’s ability to accurately integrate LCMS peaks for per- and polyfluoroalkyl substances (PFAS), even at low signal-to-noise ratios. Its AI-driven algorithms automatically identify components, integrate peaks without manual parameter adjustments, and suppress false positives from baseline noise or drift—delivering consistent, reliable quantitation in challenging conditions.

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PeakIntelligence dramatically reduces time-consuming, manual review processes by up to 67% and delivers superior reproducibility across complex analyses like PFAS quantification. Experience higher confidence in your results with automated processing that maintains accuracy while accelerating your analytical workflow.

The chromatogram below illustrates the part-per-trillion analysis of a 1 ng/L mixed standard solution of PFAS (Per- and Polyfluoroalkyl Substances). Despite the extremely low concentration of 1 ng/L, the compounds are detected with good peak intensity. The LCMS-8065XE, equipped with the innovative StreamFocus and UFsweeper IV, delivers exceptional sensitivity for the analysis of trace-level components.

The LCMS-8065XE delivers exceptional robustness in continuous analysis of complex matrices. In this test, over 10,000 consecutive injections of treated wastewater were analyzed—without using LC switching valves for matrix elimination—to intentionally create a more demanding environment. Even under these extreme conditions, the system maintained over 85% of its initial response, demonstrating outstanding durability and stability for high-throughput applications.

Championing Sustainability for a Better Tomorrow

High Energy Efficiency

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The LCMS-8065XE includes ecology mode functionality that checks the system usage status and automatically shuts down the system if it has not been used for a certain period of time. Using the ecology mode can reduce electricity consumption by about 31%. It also contributes significantly to reducing power consumption by not using LC-MS/MS peripheral equipment except during analysis. Moreover, reducing CO2 emissions contributes to achieving a carbon-neutral society.

Fast-Tracking Sustainability with Nexera UHPLC and LCMS-8065XE

• Combining the LCMS-8065XE with a Nexera series UHPLC system enables ultra-fast analysis and significantly enhances analytical throughput. This increased efficiency also leads to substantial reductions in solvent, gas, and electricity consumption, resulting in lower operational costs.

• NOTE: Power consumption calculations assume 8 hours of analysis on weekdays and no hours on weekends (with ESI interface switched OFF)
  
  Without Ecology Mode
  ESI interface remains ON after analysis.
  
  With Ecology Mode
  Ecology mode is activated after analysis (with ESI interface switched OFF).