Nexera HPLC/UHPLC Autosampler - SIL-40XR/SIL-40CXR

The beauty of our new autosamplers lies within their ability to maintain ultra-low carryover with fast injection cycles. By placing the needle in the flow path, the entire sample path is constantly being flushed with the mobile phase gradient. Injections are designed to be clean with minimum cycle times, ensuring reliable and rapid analysis. Such autosamplers can be equipped with up to 3 of our new plate changers, allowing users to reach a capacity as high as 16,000+ samples on a single system. Shimadzu’s latest cooled autosamplers can reach the set temperature in 20 minutes, critically important for heat-sensitive samples. Various automated pretreatment functions are now standard on all models, improving throughput and precision by eliminating the need for manual sample preparation. Unique co-injection pretreatment can improve the peak shape of early eluting compounds while avoiding incorrect peak integration. Dual injection mode doubles the throughput and enables 2 complementary analyses to run simultaneously on a single system, saving your precious time and space in the laboratory. LabSolutions software allows results from multiple analyses to be displayed on a single report (using our latest Multi Data Reporting option).


Request a Quote  Get Support 

SIL-40XR/SIL-40CXR Features

Discover Shimadzu’s reliable and high performance autosamplers designed for UHPLC-like applications, ideal for 3 µm FPP or 2.7 µm SPP columns. Sample carryover is significantly reduced due to the needle-in-flowpath design. Up to three plate changers can be used to expand sample capacity, with temperature control possible when coupled to the SIL-40C XR. Both autosamplers support shallow and deep-well MTP, as well as wide ranges of vial types. The SIL-40C XR model has a forced air sample cooling mechanism to protect your thermally-sensitive samples. The maximum pressure of the SIL-40 XR and SIL-40C XR is 70 MPa (700 bar) and either can be coupled with LC-40D XR UHPLC pumps.


SIL-40XR/SIL-40CXR Specifications

  • Features a needle in the flow path design to minimize carryover.
  • Standard sample loop (50 µL), an optional sample loop (2000 µL) and a fixed-loop configuration (5 or 20 µL) are available.
  • Total injection method: 0.1 to 50 µL in increments of 0.1 µL from 0.1 to 9.9 µL, and 1 µL from 10-50 µL.
  • Performs sample pretreatment including dilution, reagent addition, co-injection of samples, stacked injection, and overlapped injection.
  • Temperature control from 4 to 45°C (± 2°C accuracy,) with a forced air cooling mechanism to reduce condensation (SIL-40C XR only).
  • Industry-leading cycle time of ≤ 7 seconds.
  • Injection volume repeatability: RSD ≤1.0% for 0.5-0.9 µL, RSD ≤0.5% for 1.0-1.9 µL, RSD ≤0.25% for 2.0-4.9 µL, RSD ≤0.15% for injections ≥5.0 µL.
  • Injection volume accuracy of ±1% for 5 μL injections (n=20).
  • Carryover performance: 0.0015% (no needle rinsing) and 0.0003% (with rinse).
  • Equipped with both a static rinse port and an active rinse pump to rinse the outside of the needle before and/or after aspirating sample.
  • A 3-solvent internal rinse option is available to clean the inside of the needle and loop after sample injection to further reduce carryover.
  • A dual injection mechanism can be installed for high throughput operation or complementary analysis.
  • Maximum pressure rating of 80 MPa (800 bar).

View Full Component Spec Sheet 

Related Components

Top of This Page