OmegaTOF

MegaDalton MALDI-TOF Mass Spectrometer

Benchtop High Mass MALDI TOF Mass Spectrometer Created by Shimadzu Scientific Inc and CovalX Instruments Inc

OmegaTOF

By combining the latest performance from the Shimadzu benchtop Matrix Assisted Laser Desorption Time-of-Flight (MALDI-TOF) technology with the CovalX MegaDalton MALDI detection technology, the OmegaTOF offers the first fully integrated benchtop high mass MALDI-TOF mass spectrometer.

Built on the Shimadzu MALDI-8020 benchtop platform it features all the speed, sensitivity, and ease of use, coupled with CovalX’s dedicated experience for MegaDalton MALDI detection.

Key Features:

Patented CovalX Detection to 1.5MDa for singly charged ions
Linear mode (positive ion) MALDI-TOF
200 Hz solid-state laser, 355 nm
Load-lock chamber for fast sample introduction
Integrated barcode plate reader
Patented TrueClean™ UV-laser source cleaning
Patented WideBore™ ion optics technologies
Small benchtop footprint
Quiet operation (<55 dB)

Features

Intact Protein Complex Characterization

When coupled with the CovalX crosslinking chemistries, the extended mass range of the OmegaToF gives direct access to the characterization of complexes formed between therapeutic monoclonal antibodies (mAbs) and their antigen targets...
Sample target solutions

Compatible with the FlexiMass series of microscope slide-format sample targets, these slides provide researchers with options depending on their experimental workflow.
TrueClean automated source cleaning

To maintain instrument performance over time, the OmegaTOF features wide-bore ion optics - a feature used on our existing MALDI-TOF products - which minimize the risk of source contamination over time, providing a robust platform.
Quality as standard

Through the selection of components demonstrating improved longevity and performance, and by reducing the number of component parts, our engineers have created a reliable and robust platform capable of delivering outstanding performance in a small footprint.

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Latest Webinar

2022-09-08

OmegaTOF: Large Molecule Biotherapeutics and Protein Interactions Analysis on a Benchtop Platform

MALDI-Based Instruments and Solutions

Shimadzu, together with Covalx are excited to showcase the latest development in MALDI mass spectrometry with the OmegaTOF, a benchtop MALDI TOF featuring the latest high mass detection capabilities. This presentation will highlight the ease of use and unique technology of the OmegaTOF for the rapid analysis of large molecules and protein complexes. Research and development of monoclonal antibody (mAb) products is a growing segment of the biotherapeutic market, which has only been accelerated by the recent COVID pandemic. The analysis of non-covalent complexes by mass spectrometry is stabilized using crosslinking chemistry to allow the direct analysis of protein:protein interactions (PPI). Studies of PPI such as monoclonal antibodies with their antigens of different protein sizes and stoichiometry determination will be demonstrated, including mAb binding the novel SARS-CoV2 antigen targets. Additionally, a basic epitope binning experiment will be demonstrated using two mAbs binding onto the same target measured directly at several hundred kiloDalton with no immobilization or tagging needed. Examples will also be shown for large proteins such as Keyhole Limpet Hemocyanin (KLH) and biotherapeutic monoclonal antibody products such as Immunoglobulin G (IgG) and Immunglobulin M (IgM). These demonstrate detection of several hundreds of kiloDaltons and up to the MegaDalton range with a high level of sensitivity.

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