Chapter 4 Introduction to tandem MS systems

Liquid Chromatograph-Mass Spectrometry

Introduction to tandem MS systems

Chapter 4 introduces the core concept and key features of a MS/MS system. It includes the basic instrumentation, the collision-induced dissociation and the various scan modes in MS/MS. Tandem/Hybrid MS systems (e.g. Triple Quadrupole MS, Q-TOF, and IT-TOF) is a versatile and powerful instrument used in many applications. To gain a better understanding and to find the most suitable system for your application, the resolution, sensitivity, capabilities and strengths of these MS/MS are compared.