Analysis of Dioxins and Furans (2,3,7,8-TCDD) in Drinking Water
Dioxins and furans are the common names for two related families of environmentally persistent, toxic substances. These compounds include polychlorinated dibenzo dioxins (PCDDs) and polychlorinated dibenzo furans (PCDFs), which are unwanted by-products of industrial and natural processes, usually involving combustion. Dioxin and furan compounds vary greatly in their potential to cause adverse health effects. The most toxic of the chlorinated dioxin and furan molecules in laboratory animals is 2,3,7,8-tetachlorodibenzo-p-dioxin (TCDD).
The USEPA has regulated dioxin as 2,3,7, 8 – Tetrachlorodibenzo-p-dioxin in drinking water requiring analysis by Method 1613B, high resolution GCMS. However, in 2004, the EPA issued an Alternative Test Procedure allowing this analysis by tandem GC-MS/MS.
2,3,7,8-TCDD in drinking water may be analyzed using the Shimadzu GCMS-TQ8050 NX in samples with a turbidity less than 1 NTU.
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Quantitative Determination of Dioxins in Drinking Water by Isotope Dilution using Triple Quadrupole GC-MS/MS
Polychlorinated dibenzodioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs), generally termed as dioxins, are persistent organic pollutants. Their stabilities have been accumulating to environmental problems. In addition to the gas chromatograph coupled with high resolution mass spectrometry (GC-HRMS) system, EU regulation 589/2014 has included the use of tandem mass-spectrometry (GC-MS/MS) system as a confirmatory method for determination of dioxins in feed and food. This motivates the use of the inexpensive and user-friendly GC-MS/MS system to identify and quantify dioxins. In this study, we report a method developed with the cost-effective triple quadrupole GC-MS/MS system for high sensitivity detection and quantification of dioxins in water samples, as a proposed alternative to the EPA method 1613 with a change of detector.
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Triple Quadrupole Gas Chromatograph Mass Spectrometer
The ATP for measurement of 2,3,7,8 – TCDD in drinking water takes advantage of newer technology, such as the Shimadzu GCMS-TQ8050 NX triple quadrupole GC-MS/MS lowers laboratory capital investment and operation cost, while not compromising method performance and can easily MDL and other QC requirements of the method.