Shimadzu’s New Nexera X4 UHPLC Achieves Unmatched Sensitivity, Exceptional Separation Performance and Reliable High-Speed Analysis

Shimadzu Scientific Instruments introduces the Nexera X4 Ultra High-Performance Liquid Chromatograph (UHPLC), a next-generation system that builds on the proven technology of Shimadzu’s Nexera series. With its industry-leading low-dispersion design, the Nexera X4 UHPLC delivers superior sensitivity, ultra-sharp peaks and outstanding separation performance. Advanced fluid control technology maintains exceptional flow stability during high-speed, ultra-high-pressure analyses for consistently reliable results. The system is ideal for research and development applications in pharmaceuticals, food, environmental science and chemistry.

Features of the Nexera X4 UHPLC include:

Ultra-Fast Analysis

With its new four-drive binary pump, independently activated plungers and pressure feedback control, the Nexera X4 UHPLC enables ultra-fast analysis through highly responsive solvent delivery. The instrument cuts analysis times by 92% versus typical HPLC systems and 78% versus other UHPLC-class systems, delivering up to 14 times greater laboratory productivity.

Ultra-Sharp Peaks

The Nexera X4 incorporates Shimadzu’s Nexflow technology to minimize system-derived peak broadening through low-dispersion flow paths that maintain the internal diameter of the flow lines. This feature increases sensitivity, enables full UHPLC column performance and delivers higher separation efficiency.

Ultra-Low Solvent Consumption

Used with narrow-bore columns, the Nexera X4 UHPLC significantly reduces solvent consumption, enabling more cost-efficient and environmentally conscious analysis.

Optimized for Analytical Miniaturization

The Nexera X4 UHPLC supports analytical miniaturization through its precise micro-volume injection, accurate mobile phase delivery and low-dispersion flow paths that minimize band broadening, even with narrow-bore columns.

Maximize Mass Spectrometry Performance

The Nexflow Tubing kit reduces peak broadening between the column outlet and MS interface, leveraging the ultra-fast and high-separation performance of the Nexera X4 UHPLC and maximizing mass spectrometer performance.

A Next-Generation LCMS Platform

Paired with Shimadzu’s triple quad LCMS-TQ RX Series systems, the Nexera X4 UHPLC delivers high-speed, high-sensitivity LC-MS/MS analysis. With UFswitching™ technology, the LCMS-TQ RX Series supports positive and negative ionization switching in just 5 msec, minimizing ion intensity loss and enabling stable, high-sensitive results. Combined with the Nexera X4’s excellent gradient control, the system offers exceptional throughput for demanding analytical workflows.