Nexera X4 Ultra High-Performance Liquid Chromatograph

Precision Beyond the Column: The Nexflow Advantage

While high-performance columns are essential for minimizing band broadening and achieving superior resolution, their potential is often limited by the system itself. The Nexera X4 is engineered to bridge this gap. Featuring proprietary Nexflow technology, the system achieves ultra-low dispersion without altering the internal diameter of the flow lines. By minimizing extra-column band broadening, the Nexera X4 ensures that your hardware never bottlenecks your chemistry, resulting in higher levels of sensitivity and allowing the full separation power of your UHPLC columns to be realized.

Key Performance Benefits

• Maximize Column Efficiency: Nexflow eliminates system-derived dispersion, ensuring that the sharp peaks generated within the column reach the detector with absolute integrity.
• Superior Isocratic Performance: The Nexera X4 significantly improves theoretical plate numbers, particularly for early eluting compounds where extra-column broadening typically degrades results.
• Optimized Flow Dynamics: Maintain high-speed, high-resolution analysis without the pressure risks or clogging associated with narrowing the flow path.

Velocity Meets Veracity

The Nexera X4 redefines laboratory throughput by combining rapid responsiveness with unshakeable precision. Powered by a sophisticated four-plunger independent actuation system and a real-time pressure feedback mechanism, the Nexera X4 delivers solvents with unmatched agility—perfectly suited for the rigors of ultra-high-speed chromatography.

Unprecedented Productivity Gains

Transform your lab’s output with speed that doesn't sacrifice quality. By streamlining flow dynamics, the Nexera X4 slashes analysis times and sets a new benchmark for efficiency:

92% Faster than typical HPLC systems.

78% Faster than standard UHPLC-class instruments.

14x Productivity Increase: Accelerate your workflows and maximize sample capacity without adding overhead.

Precision at the Micro Scale

Ultra-Low Volume Micro-Injections: Equipped with a high-precision measuring pump, the Nexera X4 masters the art of the micro-injection. Achieve exceptional repeatability even with injection volumes of 1 μL or less, ensuring accuracy for your most precious samples.

Highly Responsive Solvent Delivery: Miniaturized workflows depend on stable, minute flow rates. The Nexera X4’s optimized internal volume is specifically engineered for gradient analysis with narrow-bore columns, providing the responsiveness needed for sharp, consistent transitions.

Preserved Separation with Nexflow: Analytical miniaturization often risks increased band broadening. Our proprietary Nexflow technology mitigates this by streamlining flow channels, ensuring that your separation performance remains elite—even as your scale gets smaller.

Optimize Your MS Interface with Nexflow Tubing

To truly unlock the power of Mass Spectrometry, the connection between your LC and MS must be seamless. The Nexflow Tubing for MS is a dedicated high-performance kit engineered specifically for the Nexera X4, designed to eliminate the resolution loss that often occurs between the column outlet and the MS interface. By preserving the integrity of your separation right up to the point of detection, this kit ensures that your Mass Spectrometer receives the sharpest, most concentrated peaks possible.

The Ultimate Power Couple: Nexera X4 & LCMS-8060 Series

Unmatched Throughput. Uncompromising Sensitivity.

When the precision of the Nexera X4 meets the speed of the LCMS-8060 Series, the result is a next-generation analytical platform that redefines the boundaries of high-speed, high-sensitivity analysis. This synergy transforms complex workflows into streamlined, high-performance operations.