Shimadzu Introduces the CF3-C8030 Centrifugal Field-Flow Fractionation System for Advanced Nanoparticles & Biomolecules Separation

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Shimadzu Scientific Instruments (SSI) announces the release of its CF3-C8030 Centrifugal Field-Flow Fractionation system designed to improve the separation and analysis of nanoparticle drug delivery systems and other complex pharmaceutical and biopharmaceutical formulations. In addition, the system is ideal for materials science applications, particularly electronics and semiconductor manufacturing.

The CF3-C8030 unit improves analytical capabilities by separating particles prior to analysis, enabling high-resolution characterization across a broad particle size range. This physical separation of particle populations helps eliminate interference and provides an accurate view of true particle size populations, including those difficult or impossible to resolve using conventional particle measurement methods.

High-Resolution Separation Across a Wider Size Range

The new CF3-C8030 unit achieves superior separation performance through centrifugal forces up to 15,900 × g, allowing users to resolve closely sized particle populations with exceptional clarity. Increasing relative centrifugal force (RCF) directly improves resolution. In comparative studies evaluating mixed silica nanoparticles (30, 40 nm, 50 nm, 60 nm and 70 nm), higher initial RCF values resulted in significantly improved separation of individual particle sizes. This capability is especially valuable for the analysis of smaller nanoparticles and complex multimodal samples.

Versatile Integration with Analytical Technologies

The CF3-C8030 system supports flexible integration with a variety of complementary technologies, including multiple detector types and electron microscopy for detailed examination of fractionated samples. This adaptability enables comprehensive characterization workflows essential for advanced pharmaceutical and materials research.

In addition to nanoparticle drug delivery system analysis, the CF3-C8030 is ideal for pharmaceutical and materials science applications including gene therapies, vaccines and protein analysis characterization, novel formulation development, biopharmaceutical R&D, conductive materials, and semiconductor manufacturing.