Response to AOAC's Call for Methods: PFAS
Shimadzu’s response to AOAC’s call for methods, addressing all PFAS required of the SMPR in 11 matrix categories:
To address AOAC’s call for methods, we developed an LCMS/MS method testing all 30 compounds for all 11 matrices. Our flexible prep workflow is designed to save you time and money, while all samples can be run using the Shimadzu Nexera Liquid Chromatograph coupled to a Shimadzu LCMS-8060NX triple quadrupole mass spectrometer.
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The use of EPA 1633 for animal tissues raised a need for PFAS screening in products meant for human consumption. AOAC, the standards organization for food safety and food testing, responded to the need by calling for methods and detailed method needs in their SMPR 2023.003.
Shimadzu was one of 4 responders to AOACs SMPR 2023.003 on targeted analysis of PFAS in foods covering all 30 PFAS and 11 food categories. Now accepted as a First Action method, the method developed on the Shimadzu TQ LCMS 8060NX will be in Official Methods of Analysis for general use.
To make the method as streamlined as possible, we had the samples follow the same general procedure. Generally, all samples were homogenized, processed with QuEChERS where needed, cleaned up with SPE, then concentrated if needed before injection to the TQ LCMS 8060NX.
Where we found a step did not improve results, we skipped it – saving laboratories consumables, time, and money.
Accepted for the OMA, the method met or exceeded the needs of SMPR 2023.003. We continue to work with AOAC for PFAS testing in food contact materials, and with ASTM for other consumer products.
As Seen at AOAC Annual Conference 2024
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Determination of 30 PFAS in Eggs, Produce, Seafood, Protein Powder, and Baby Food by LC-MS/MS
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Determination of 30 PFAS in Fish and Pet Food by LC-MS/MS
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Determination of 30 PFAS in Milk by Liquid Chromatography Triple Quadrupole Mass Spectrometry (LC-MS/MS)
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Determination of PFAS in Fish Oil, Offal and Coffee by LC-MS/MS
Detailed Applications per Matrix Category
Determination of 30 PFAS in Foods for Infants and Young Children (Baby Food) by Liquid Chromatography Triple Quadrupole Mass Spectrometry (LC-MS/MS)
To address AOAC’s call for methods, a single instrument method was developed to address PFAS in all 11 food categories. We discuss each matrix category from the SMPR separately. In this application news, we describe a single laboratory validation study with a rapid extraction of low concentrations of 30 PFAS in pumpkin and sweet potato puree baby food using the QuEChERS technique followed by analysis using the Shimadzu Nexera Liquid Chromatograph coupled to a Shimadzu LCMS-8060NX triple quadrupole mass spectrometer.
Determination of 30 PFAS in Egg by Liquid Chromatography Triple Quadrupole Mass Spectrometry (LC-MS/MS)
To address AOAC’s call for methods, a single instrument method was developed to address PFAS in all 11 food categories. We discuss each matrix category from the SMPR separately. In this application news, we describe a single laboratory validation study with a rapid extraction of low concentrations of 30 PFAS in eggs using the QuEChERS technique followed by analysis using the Shimadzu Nexera Liquid Chromatograph coupled to a Shimadzu LCMS-8060NX triple quadrupole mass spectrometer.
Determination of 30 PFAS in Fish by Liquid Chromatography Triple Quadrupole Mass Spectrometry (LC-MS/MS)
To address AOAC’s call for methods, a single instrument method was developed to address PFAS in all 11 food categories. We discuss each matrix category from the SMPR separately. In this application news, we describe a single laboratory validation study with a rapid extraction of low concentrations of 30 PFAS in fish using the QuEChERS technique followed by analysis using the Shimadzu Nexera Liquid Chromatograph coupled to a Shimadzu LCMS-8060NX triple quadrupole mass spectrometer.
Determination of 30 PFAS in Protein Powder by Liquid Chromatography Triple Quadrupole Mass Spectrometry (LC-MS/MS)
To address AOAC’s call for methods, a single instrument method was developed to address PFAS in all 11 food categories. We discuss each matrix category from the SMPR separately. In this application news, we describe a single laboratory validation study with a rapid extraction of low concentrations of 30 PFAS in protein powder using the QuEChERS technique followed by analysis using the Shimadzu Nexera Liquid Chromatograph coupled to a Shimadzu LCMS-8060NX triple quadrupole mass spectrometer.
Determination of 30 PFAS in Pet Food by Liquid Chromatography Triple Quadrupole Mass Spectrometry (LC-MS/MS)
To address AOAC’s call for methods, a single instrument method was developed to address PFAS in all 11 food categories. We discuss each matrix category from the SMPR separately. In this application news, we describe a single laboratory validation study with a rapid extraction of low concentrations of 30 PFAS in pet food using the QuEChERS technique followed by analysis using the Shimadzu Nexera Liquid Chromatograph coupled to a Shimadzu LCMS-8060NX triple quadrupole mass spectrometer.
Determination of 30 PFAS in Produce by Liquid Chromatography Triple Quadrupole Mass Spectrometry (LC-MS/MS)
To address AOAC’s call for methods, a single instrument method was developed to address PFAS in all 11 food categories. We discuss each matrix category from the SMPR separately. In this application news, we describe a single laboratory validation study with a rapid extraction of low concentrations of 30 PFAS in carrots using the QuEChERS technique followed by analysis using the Shimadzu Nexera Liquid Chromatograph coupled to a Shimadzu LCMS-8060NX triple quadrupole mass spectrometer.
Determination of 30 PFAS in Offal by Liquid Chromatography Triple Quadrupole Mass Spectrometry (LC-MS/MS)
To address AOAC’s call for methods, a single instrument method was developed to address PFAS in all 11 food categories. We discuss each matrix category from the SMPR separately. In this application news, we describe a single laboratory validation study with a rapid extraction of low concentrations of 30 PFAS in beef kidney using Acetonitrile and Solid Phase Extraction (SPE) followed by analysis using the Shimadzu Nexera Liquid Chromatograph coupled to a Shimadzu LCMS-8060NX triple quadrupole mass spectrometer.
Determination of 30 PFAS in Milk by Liquid Chromatography Triple Quadrupole Mass Spectrometry (LC-MS/MS)
To address AOAC’s call for methods, a single instrument method was developed to address PFAS in all 11 food categories. We discuss each matrix category from the SMPR separately. In this application news, we describe a single laboratory validation study with a rapid extraction of low concentrations of 30 PFAS in milk using the QuEChERS technique followed by analysis using the Shimadzu Nexera Liquid Chromatograph coupled to a Shimadzu LCMS-8060NX triple quadrupole mass spectrometer.
Determination of 30 PFAS in Fish Oil by Liquid Chromatography Triple Quadrupole Mass Spectrometry (LC-MS/MS)
To address AOAC’s call for methods, a single instrument method was developed to address PFAS in all 11 food categories. We discuss each matrix category from the SMPR separately. In this application news, we describe a single laboratory validation study with a rapid extraction of low concentrations of 30 PFAS in fish oil followed by analysis using the Shimadzu Nexera Liquid Chromatograph coupled to a Shimadzu LCMS-8060NX triple quadrupole mass spectrometer.
Determination of 30 PFAS in Coffee by Liquid Chromatography Triple Quadrupole Mass Spectrometry (LC-MS/MS)
To address AOAC’s call for methods, a single instrument method was developed to address PFAS in all 11 food categories. We discuss each matrix category from the SMPR separately. In this application news, we describe a single laboratory validation study with a rapid extraction of low concentrations of 30 PFAS in brewed coffee followed by analysis using the Shimadzu Nexera Liquid Chromatograph coupled to a Shimadzu LCMS-8060NX triple quadrupole mass spectrometer.
Determination of 30 PFAS in Seafood by Liquid Chromatography Triple Quadrupole Mass Spectrometry (LC-MS/MS)
To address AOAC’s call for methods, a single instrument method was developed to address PFAS in all 11 food categories. We discuss each matrix category from the SMPR separately. In this application news, we describe a single laboratory validation study with a rapid extraction of low concentrations of 30 PFAS in shrimp using the QuEChERS technique followed by analysis using the Shimadzu Nexera Liquid Chromatograph coupled to a Shimadzu LCMS-8060NX triple quadrupole mass spectrometer.