Forensics Resource Library
Identification and Confirmation of Ten Common Seized Drugs Utilizing an LCMS-2020 Single Quadrupole Mass Spectrometer
The use of illicit drugs continues to be an epidemic across the United States. Currently most laboratories require the use of a GC or GCMS system and a cumbersome derivatization step to analyze seized drugs. By utilizing a LCMS method, faster detection rates and a larger drug panel could be screened simultaneously. The need for a derivatization step could also be avoided.
Quantification and Simultaneous In-Source Fragmentation of 16 Cannabinoids in Hemp Using Single Quadrupole LC-MS
In this extended study, an LC-MS method of quantitation and simultaneous SID was developed using the LCMS-2020 single quadrupole MS with an integrated LC front end (LC 2040C 3D) for the quantification of 16 cannabinoids, including Δ9-tetrahydrocannabinol (Δ9-THC), Δ8-tetrahydrocannabinol (Δ8-THC), cannabidiol (CBD), cannabigerol (CBG), cannabinol (CBN), cannabicyclol (CBL) and their respective acidic forms, etc. Selected ion monitoring (SIM) was used for quantitation, simultaneous positive and negative scans were used for identification.
Tocopherol (Vitamin E) Analysis in Vaping E-Liquid by UHPLC-PDA
Vaping illnesses have been a growing concern for the CDC with over 2,000 known cases and 39 confirmed deaths so far (CDC – November 2019). It is unclear what is causing the illnesses, but vitamin E acetate has been identified as a possible contributor. Vitamin E acetate has been found in the bronchoalveolar lavage (BAL) fluid for all currently tested samples by the CDC (CDC – November 2019). Two methods have been developed using photodiode array detection (PDA) to separate three isomers of tocopherol (vitamin E): alpha-tocopherol acetate, alpha-tocopherol, and gamma-tocopherol.
Quantitative Analysis of 16 Cannabinoids with Complete Baseline Separation of Δ8 and Δ9-THC Utilizing the Triple Quad LCMS-8050
The following method application is driven by the potential terpenes interferences with THC quantitation when analyzing fortified Cannabis products on an HPLC system with a UV or PDA detector. Generally, terpene interference is not a problem as naturally occurring terpenoid content does not exceed 0.2% of the total and terpenes are lost in the baseline under the currently run gradient conditions with HPLC-UV or UHPLC-PDA. However, a sample that has been fortified with excess terpene content may face co-elution issues of the terpenes with individual cannabinoids because the terpenes are also quite hydrophobic and exhibit similar retention on the column as the cannabinoids.
Guidebook & Journals
Title: Thermal Desorption GCMS: Supporting Your Arson Analysis
Duration: 1 hour
Featured Shimadzu Applications
- Direct Determination of Pb in Whole Blood by Graphite Furnace Atomic Absorption Spectrophotetry (GF-AAS)
- Analysis of ICP-Atomic Emission Spectrometry in Accordance with the ICH Q3D Guideline for Elemental Impurities Using ICPE-9820
- Quantitation of Trace Elements in Blood Using Shimadzu ICPMS-2030 Inductively Coupled Plasma Mass Spectrometer
- Identification and Confirmation of Ten Common Seized Drugs Utilizing an LCMS-2020 Single Quadrupole Mass Spectrometer
- In-Source Fragmentation of 16 Cannabinoids Using Single Quadrupole LC-MS
- Quick Turnaround Analysis of 8 Drugs for Driver Under Influence Using LDTD-MS/MS System
- Analysis of Postmortem Samples Using Automated Sample Preparation Coupled Directly to LC-MS/MS
- Analysis of Ethlyglucuronide and EthlySulfate in Urine, Plasma and Serum by LCMS-8050 using RECIPE ClinMass LC-MS/MS Complete Kit MS8000
- A Novel Platform of On-Line Sample Pre-Treatment and LC-MS/MS Analysis for Screening and Quantitation of Illicit Drugs of Abuse
- Quantitation of Ethyl Glucuronide and Ethyl Sulfate in Urine using LC-MS/MS
- Analysis of Doping Agents Using Ultrafast LC-MS/MS with Scheduled MRM
- Analysis of Steroids and NSAIDs Using the Shimadzu LCMS-8050 Triple Quadrupole Mass Spectrometer