Shim-pack Bio Diol & IEX Columns

Solutions for the analysis of peptides, oligonucleotides, and biopharmaceuticals

The accurate analysis of biopharmaceutical compounds is needed when developing high quality pharmaceuticals. Shim-pack Bio Diol and IEX columns will improve the accuracy of the characterization of peptides, oligonucleotide and other biopharmaceuticals.

Shim-pack Bio Diol – Size Exclusion Columns

Rapid mAb Aggregate Analysis using 2µm Shim-pack Diol-300 column

With different pore sizes, Shim-pack Bio Diol LC columns are effective for analysis of aggregates and fragments of mAb, oligonucleotides and carbohydrates. By reducing the particle size from 5μm to 2μm, the resolution between aggregates and monomers was greatly improved. Furthermore, by reducing the column length from 300mm to 150mm using a 2μm particle, 50% less run time was achieved, while maintaining resolution as compared to the original method that used a 5μm, 4.6 × 300mm column.

Get better resolution in half the time!

Shim-pack Bio Diol Diol-60 Diol-120 Diol-200 Diol-300
Particle Silica
Ligand Dihydroxypropyl(Diol)
Particle Size 3μm, 5 μm 2 μm, 3 μm, 5 μm
Pore Size 6 nm 12 nm 20 nm 30 nm
pH Range 5.0 - 7.5
Molecular Weight Range below 10,000 1,000 - 100,000 5,000 - 300,000 20,000 - 1,000,000

(Click on the part number below to be transferred to our web store where you can purchase the column)

  Molecular Weight Range
Below 10,000 1,000 - 100,000
Particle
Size 
(µm)
Length (mm) 4.6 8.0 20 4.6 8.0 20
3 300 227-31007-01     227-31008-01    
5 300 227-31007-02 227-31007-03 227-31097-01 227-31008-02 227-31008-03 227-31098-01
500     227-31097-02     227-31098-02
  Molecular Weight Range
5,000 - 300,000 20,000-1,000,000
Particle
Size 
(µm)
Length (mm) 4.6 8.0 20 4.6 8.0 20
2 150     227-31010-01    
300 227-31009-02     227-31010-02    
3 300 227-31009-03     227-31010-03    
5 300 227-31009-04 227-31009-05 227-31099-01 227-31010-04 227-31010-05 227-31100-01
500     227-31099-02     227-31100-02
 
 

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Shim-pack Bio IEX – Ion Exchange Columns

Shim-pack Bio IEX Columns are available in Q (quaternary ammonium) and SP (sulfopropyl) chemistries and are based on porous (Q and SP columns) and non-porous (Q-NP and SP-NP columns) hydrophilic polymers with low nonspecific adsorption. The porous particles offer excellent binding capacity with exceptionally high efficiency and the non-porous particles offer high efficiency and exceptional resolution.

Analysis of Synthesized Oligonucleotide (Single Strand DNA) using Shim-pack BIO IEX Q-NP

Shim-pack Bio IEX Q-NP SP-NP Q SP
Particle hydrophilic non-porous polymer hydrophilic porous polymer
Particle Size 3 μm, 5 μm 5 μm
Ligand - CH2N+(CH3)3 - (CH2)3SO3- - CH2N+(CH3)3 - (CH2)3SO3-
pH Range 2 - 12

(Click on the part number below to be transferred to our web store where you can purchase the column)

Click here for pricing and ordering information 

 

For Research Use Only. Not for use in diagnostic procedures.

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