Workflow Automation Features
- Centralized system control
- Stream-specific status monitoring
- Automated schedule management
- Spreadsheet and CSV batch imports
- Integrated data acquisition and reporting
- Seamless connectivity with LabSolutions Insight
Nexera QX Multiplex LC-MS/MS System - Features
High-Throughput UHPLC-MS/MS
High-Throughput Multiplex LC-MS/MS
| Modern laboratories need to process more samples, deliver faster results, and maximize the value of existing analytical instrumentation. Nexera QX combines multiplex UHPLC-MS/MS technology with automated workflow management to increase throughput, reduce analysis time, and improve laboratory efficiency. |
| The Nexera™ QX Multiplex LC-MS/MS System was developed specifically for laboratories that require higher throughput from existing LC-MS/MS resources. By coordinating two or four UHPLC streams with a single mass spectrometer, Nexera QX increases sample throughput while preserving chromatographic performance and analytical quality. |
| Unlike conventional LC-MS/MS workflows, where instrument cycle time includes injection, rinsing, equilibration, and data acquisition, Nexera QX uses multiple alternating sample introduction streams to keep the mass spectrometer continuously productive. The result is significantly improved laboratory throughput without the need for additional mass spectrometers. |
Maximize Mass Spectrometer Utilization
Mass spectrometers deliver value when they are collecting data. In traditional LC-MS/MS workflows, significant instrument time is consumed by column equilibration, autosampler rinsing, and column flushing steps that do not generate analytical data.
Nexera QX 1 SIL System
Nexera QX reclaims lost productivity through Multiple Stream Technology, which alternates UHPLC flow paths to maintain continuous mass spectrometer operation. While one stream acquires analytical data, other streams simultaneously perform preparation, washing, and equilibration activities.
The result is greater instrument productivity, better utilization of existing assets, and increased return on investment.
Benefits
- Reduce mass spectrometer idle time
- Increase instrument utilization
- Improve ROI of existing LC-MS/MS systems
- Increase sample throughput without adding another MS
- Maximize value from laboratory capital investments
Purpose-Built for Multiplex UHPLC-MS/MS
Integrates Nexera UHPLC hardware, SIL-40 autosamplers, intelligent stream control, and dedicated fluidics into a single multiplex platform.
Nexera QX was engineered for multiplex UHPLC-MS/MS operation and integrates dedicated hardware designed specifically for coordinated multi-stream analysis.
Built around the high-performance SIL-40 series autosampler platform, the system incorporates stream-dedicated valves, needle ports, and fluidic pathways to support reliable operation across up to four analytical systems. This architecture minimizes dead volume, supports ultra-fast injections, and enables scalable high-throughput workflows.
Automated LC-MS Workflow Management
QX Solution software provides a single point of control for the entire multiplex LC-MS/MS workflow, from sample introduction through data acquisition and error handling. Designed specifically for high-throughput laboratories, QX Solution simplifies operation while maximizing productivity.
The software coordinates injection timing, stream switching, gradient synchronization, and flushing procedures while providing dedicated stream monitoring and intelligent batch management. Integration with LabSolutions™ Insight supports efficient quantitative workflows from sample submission through report generation.
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Productivity Beneftis
- Simplified operation
- Reduced operator burden
- Improved workflow consistency
- Faster batch processing
- Enhanced laboratory efficiency
Powered by Shimadzu LC-MS Technology
UFMS-enabled Shimadzu LC-MS/MS systems deliver speed, sensitivity, and robustness for high-throughput workflows.
A multiplex LC system can only be as productive as the mass spectrometer it supports. Nexera QX is designed to leverage the speed, sensitivity, and robustness of Shimadzu LC-MS/MS platforms, enabling laboratories to increase throughput without sacrificing analytical performance.
When combined with Shimadzu UFMS-enabled LC-MS/MS systems, Nexera QX delivers the acquisition speed necessary to support narrow UHPLC peaks while maintaining reliable quantitative performance across demanding high-throughput applications. The result is a fully integrated single-vendor solution optimized for productivity, reproducibility, and long-term operational reliability.
Performance Advantages
- High-speed quantitative LC-MS/MS
- Fast acquisition for UHPLC applications
- Proven sensitivity and robustness
- Fully integrated hardware and software ecosystem
- Optimized for high-throughput laboratories
- Single-vendor workflow from sample introduction through data analysis
CoreSpray™ technology for the Nexera QX provides stable, high-efficiency ionization that supports the sensitivity, robustness, and reproducibility required for high-throughput LC-MS/MS workflows.
Low Carryover and Online Sample Cleanup
Nexera HPLC/UHPLC Autosampler - SIL-40 Series
| Dedicated stream pathways, automated rinsing, and online sample cleanup capabilities support reliable quantitative performance. |
| As sample throughput increases, carryover management becomes increasingly important. Nexera QX combines the low-carryover design of the SIL-40 series autosampler with automated rinsing functions and intelligent workflow management to support reliable quantitative analysis. |
| The SIL-40 platform utilizes a linear sample loop and needle configuration that minimizes dead volume and reduces carryover. In addition, QX Solution software incorporates Analytical Intelligence functions capable of detecting high-concentration samples, triggering automated rinse sequences, and evaluating residual carryover before normal operation resumes. |
| For demanding matrices, Nexera QX also supports automated online sample cleanup using online SPE and 2D-LC trap-and-elute workflows to reduce manual sample preparation while increasing throughput. |
Automatic Rinsing Function
User defined settings enable QX Solution software to detect a high concentration sample and mitigate carryover before it occurs. Blank checks can be automatically run and evaluated for return to normal operation on all streams.
