New i-Series Integrated UHPLC Systems

The need for a more flexible work style, driven by increased automation, while attaining consistent, high-quality results for all users, continues to grow among chromatographers. Shimadzu answers this need with its new line of i-Series integrated HPLC/UHPLC systems. Redefining integrated LC technology by adding innovative, intelligent and intuitive features to existing performance excellence, the new integrated i-Series HPLC/UHPLC delivers outstanding data quality, improved workflow efficiency, and maximum uptime. Finally, an LC as smart and flexible as you!

Our New, Advanced i-Series Systems Build On A Tradition Of Excellence


Learn more about the i-Series Integrated UHPLC System


The new, integrated i-Series LC system keeps the excellent performance of its predecessor but also addresses the demands of an increasingly varied range of users, locations, and approaches to analysis while always delivering highly reliable analytical results.


Experience a new approach to analysis activities with the new i-Series. Times now call for an analytical environment that can deliver identical results regardless of whether the analyst is present in the laboratory or familiar with the operating procedures, as long as the analyst performs the same operations and data analysis.

New i-Series Model Options and Key Distinctions

Model Efficiency Sample Cooling Built-In Detector
LC-2050 7,000 psi No Sample Cooling UV Detector
LC-2050C 7,000 psi Sample Coolling UV Detector
LC-2050 3D 7,000 psi No Sample Cooling Diode Array Detector
LC-2050C 3D 7,000 psi Sample Cooling Diode Array Detector
LC-2060 10,000 psi Sample Cooling UV Detector
LC-2060 3D 10,000 psi Sample Cooling Diode Array Detector
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Analytical Intelligence

Welcome to the future of HPLC. Artificial intelligence (AI) is all around us. Every day we see new uses emerge to help make everyday tasks more efficient and solve problems across multiple industries. From digital personal assistants like Alexa to self-driving trucks to automated manufacturing facilities, AI technologies are changing the way we live, work and do business. And now, this new technology can also help analytical scientists maximize the accuracy and repeatability of their LC analysis. Using new and exciting technologies to help you increase throughput, improve accuracy and protect valuable columns, Shimadzu is delivering what you need for continued success. Not just artificial intelligence—ANALYTICAL INTELLIGENCE™.

ANALYTICAL INTELLIGENCE brings the power of artificial intelligence to your laboratory, transforming your laboratory from manual, tedious chromatography to automated, intelligent workflows that optimize resource allocation, increase throughput and reduce instrument downtime.

ANALYTICAL INTELLIGENCE integrates M2M, IoT, and Artificial Intelligence (AI) functionality, enabling higher productivity, maximum reliability, improved automated workflows, advanced remote operation, mobile phase monitoring and self-diagnosis and auto-recovery.

Using our new, advanced i-Series, you can deliver new analytical insights, drive operational efficiencies and increase equipment uptime. Read more about key ANALYTICAL INTELLIGENCE features below and contact us to learn more!


mobile phase monitor

Mobile Phase Monitor

The i-Series Mobile Phase Monitor uses real-time, measurement of the solvents and warns you if you don’t have enough to complete the batch.

  • Available in both 1L and 5L bottle sizes (or a combination). 
  • Monitoring on smart devices - PC / iOS / Android



UHPLC columns can be damaged by sudden pump starts as well as extreme gradient changes. This is especially true with polymeric packings. That’s why the Nexera UHPLC series delivers the highest level of column protection by providing a new approach to flow control. The Nexera automatically uses Smart Flow Control to increase the flow rate gradually to the set point. This unique feature helps extend the life of your columns and keeps your system running efficiently.

Smart flow control - i-Series


The i-Series now uses Smart Flow Control, ramping the flow rate gradually to the set point according to the status of the column oven.


1. The flow rate is gradually increased up to half of the set value.


2. The flow rate is kept constant until the oven is ready


3. The flow rate is gradually increased up to set the value.


Intelligent Peak Deconvolution with i-PDeA II


Achieving baseline separation of LC target components can be difficult and time-consuming, co-eluting peaks are common.

i-PDeA II makes the deconvolution of peaks simple and automatic. The result is a virtual separation that can be used for quantitative determinations.

i-PDeA II Peak Deconvolution - i-Series




Simplified User Interface

i-Series - simplified user interface

Streamline operations and improve workflows with the new i-Series intuitive user interface. The easy to use, easy-access front panel based interface replicates the system flow channel and simplifies the operating status of the system. Method editing can also be easily performed directly from the same screen. With this intuitive design, even users who are completely new to liquid chromatography can navigate the user interface with minimal training.

I-series QR Codes

The i-Series colorful LCD touch screen user interface uses animated flow channels to replicate the 4-channels of instrument solvent flow. Operating status can be checked at a glance. Chromatography conditions may be changed on the same screen, and even users new to chromatography can navigate controls with minimal training.

The LCD touch screen features QR codes, allowing you to access web-based instructional videos right from your smart device. For example, ‘How to change out pump consumables’.


Simplified Instrument Switching with Easy Method Migration


Migrating a test method (analytical conditions or method) from one instrument to another while obtaining the same chromatogram can be a challenging process. The i-Series is designed with the same internal system volumes as previous Shimadzu systems and competitor systems to ensure system compatibility and data reproducibility. The Analytical Condition Transfer and Optimization (ACTO) function also adjusts gradient start time automatically, so personnel can make easy adjustments to separations obtained by gradient analysis.


The LabSolutions Unified Laboratory Management System

LabSolutions Unified Laboratory Management System Diagram

The LabSolutions software platform is Shimadzu’s ULMS systems. It provides a single, easy to use interface for multiple types of Shimadzu instruments. LabSolutions ULMS provides extremely efficient laboratory workflows while still providing the high level functionality and data management that our customers have come to expect from all Shimadzu products.

When multiple types of instruments are included on the same LabSolutions ULMS network laboratory efficiency for the entire analytical laboratory is greatly increased. All Shimadzu laboratory instruments on the LabSolutions network can be stored in a central secure LabSolutions database. Since all laboratory data is being stored in the same database using a single software platform it becomes possible combine data from multiple instruments and multiple types of instruments into single unified reports.

With Shimadzu’s electronic records and Electronic signature capabilities customers can be assured that all data generated in the laboratory by any Shimadzu instruments meets all current regulatory requirements.

The Shimadzu LabSolutions ULMS system can acquire data from the following Shimadzu instruments LC, GC, LCMS, LC/MS/MS, GCMS, ICPMS, UV, IR, RF, Thermal Analysis, Balances, TOC-L, EDX, and ICP. The Shimadzu LabSolutions ULMS system can also acquire data from some non-Shimadzu instruments as well.

HPLC Webinars

Shimadzu Webinars

Learn more below about some of our featured HPLC webinars. To see our full lineup of our webinars, click here.


For Research Use Only. Not for use in diagnostic procedures.

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