Very fast separation speed due to the relatively low viscosity of supercritical fluid...
Nexera UC
Supercritical Fluid Extraction / Supercritical Fluid Chromatograph
Supercritical Fluid Extraction/Chromatograph System
Conventional LC/MS and GC/MS face these challenges.

Time-consuming sample preparation
Degradation of labile compounds during sample preparation
Low abundant peaks hidden in noise
Nexera UC provides uncompromising solutions.
Fully automated on-line sample preparation and analysis
Even labile compounds can be analyzed without degradation
Unified speed of analysis, sensitivity, and resolution
Just another chromatographic technique... or the only technique you'll need?

Nexera UC improves your analytical workflow by utilizing a completely new separation technology, Unified Chromatography, which unites sample preparation, analysis with various separation modes, and high-sensitivity detection.
Comparison of QuEChERS sample preparation and Nexera UC in the analysis of residual pesticides
A typical sample preparation takes 35 minutes and requires several manual steps. With Nexera UC, the same sample can be ready for on-line SFE/SFC analysis in as little as five minutes with only a few simple sample preparation steps.

* "Miyazaki Hydro-Protect", Patented in Japan No.3645552
Hundreds of compounds are simultaneously analyzed with Nexera UC. These include pesticides that are usually analyzed with LC and LC/MS/MS or GC and GC/MS/MS. Nexera UC enables analysis of compounds over a wide polarity range.

Analysis of Compounds with Wide Polarity Range
Awards
2015 R&D magazine Award

The award from R&D magazine recognizes Shimadzu’s Nexera UC system as one of the 100 most technically significant new products of the year in the analytical and testing category.
R&D Magazine chose the Nexera UC system because its fully automated technology opens up new analytical opportunities in many fields, including food products, drug discovery and delivery, chemicals, pharmaceuticals, and cleaning validation.
With industry-leading throughput and superior levels of sensitivity, the system eliminates the need for complicated sample pre-treatment and reduces the possibility of human error during analysis.
Pittcon Editors' Gold Award 2015
The Pittcon Editors' Awards recognize the most innovative products presented at Pittcon for the first time based on votes by the media corps.
Editors awarded the Nexera UC for its ability to provide a workflow solution that addresses the bottleneck in real-world sample analyses.

Features
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Solutions provided by Nexera UC
Very fast separation speed due to the relatively low viscosity of supercritical fluid...
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Improved separation and detection capabilities result from the low viscosity and high diffusion coefficient of...
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Supercritical fluid has unique properties different from liquid.
Using SFC in front of a mass spectrometer offers...
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Low dead volume back pressure regulator suppresses diffusion of peaks and can transfer the total eluate directly to an mass spectrometer to...
Movies
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Simplifying Medicinal Chemistry Workflows Using Shimadzu Nexera UC Prep
Medicinal chemists need to quickly purify a wide range of drug candidates and intermediates. The Shimadzu Nexera UC Prep semi-preparative supercritical fluid chromatography system delivers outstanding performance in a compact footprint to provide you with the fastest, most accurate and most reliable results.
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Nexera UC Supercritical Fluid Extraction/Chromatograph System Narration Eddition
News / Events
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AAPS Pharm Sci 360 - 2022
October 17-19
Boston Convention Center, Level 0
Boston, Massachusetts
Booth #1124
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American Chemical Society – Fall 2022
August 21-25
McCormick Place
Chicago, Illinois
Booth # 605
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New Nexera™ XS inert UHPLC System Eliminates Challenges of High-Concentration Mobile Phases to Achieve High Sensitivity and Reliability
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HPLC 2022
June 20-22 2022
San Diego, CA -
Cannabis Science Conference West 2022
May 18 2022 - May 22 2022
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Shimadzu’s New Analytical HPLC Method Development Support Software Follows “Quality-by-Design” Principle Using Design of Experiments