The Use of EDXRF for USP<735> Analysis

The Use of EDXRF for USP<735> Analysis Banner

Following the issuance of the ICH Q3D guideline, the United States Pharmacopeia (USP) established XRF methodology as a general chapter: <735>, X-RAY FLUORESCENCE SPECTROMETRY, in May 2015. This chapter was implemented in 2018. This paper provides background on the new regulations and the XRF technique.

Key features/benefits of EDXRF spectrometry:

  • Non-destructive analysis of solids, liquids, and powders with minimal to no sample prep required
  • 21 CRF Part 11 compliant software package
  • Low cost of ownership—no gases or chemicals needed to run
  • Easy to install—requires minimal bench space and ventilation is not necessary 
  • Easy to use—analysis is as simple as loading a sample and pressing start

Four easy steps:

4 Easy steps for EDXRF for USP<735> Analysis



For Research Use Only. Not for use in diagnostic procedures.

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