Nexera series - Modular UHPLC/HPLC Systems - Options
Ultra High Performance Liquid Chromatograph
LabSolutions Chromatography Software
The i-PeakFinder tool can automatically recognize peaks even in complex chromatograms with high noise, and accounts for baseline drift for higher integration accuracy. Adjustable parameters in i-PeakFinder, such as peak detection threshold, allow the user to detect smaller peaks. In addition, the i-PDeA II function can quantify peaks that cannot be completely separated by a column. Separate peaks by simply specifying the time and wavelength in LabSolutions.
It is important to use the most appropriate column in your LC system to achieve the highest efficiency and most accurate chromatograms. The Shim-pack series consists of a range of columns designed with the increased capabilities of the Nexera in mind. The superior ruggedness of Shim-pack columns ensures a long lifetime even with demanding sample matrices.
The superficially porous particle (SPP) technology allows for optimum separation and analysis times. The range of column types available enables you to choose the most appropriate column for each application.
Shim-pack™ XR-ODS II & III
Although the Shim-pack XR-ODS II has a particle size of 2.2 μm, it can be used up to a pressure of 60 MPa, making it appropriate for a wide range of analyses. The particle size of the XR-ODS III column has been reduced to 1.6 μm. With a maximum pressure of 100 MPa, it achieves high separation even with a short column length.
These columns are suitable for shortening analysis times while taking full advantage of the high separation power of UHPLC.
The Shim-pack GIS/GIST/GISS series lineup includes columns with particle sizes ranging from 5 μm, appropriate for HPLCs, to 2 μm, appropriate for UHPLCs. With a variety of substrates available, they are ideal for method development.
|GIS Series:||HPLC columns packed with a high-purity silica gel material as a base. With high particle uniformity to secure the mobile phase path, these columns are ideal for low-pressure analysis.|
|GIST Series:||An increase in the inertness of the silica results in improved peak shapes and ruggedness. Can be used in pH 1–10 environments. Easy to use for a wide range of chemicals and environments.|
|GISS Series:||Adding to the advantages of the GIST series, a faster elution time has been achieved to provide even sharper peaks.|
Excellent stability and performance could be achieved under a wide range of LC conditions with Shim-pack Scepter LC columns, which are the next generation organic silica hybrid based columns. With different chemistry characteristics, Shim-pack Scepter columns are effective for method development/scouting with suitability for use in a wide variety of applications. With different particle sizes (1.9 μm, 3 μm, 5 μm) and different column dimensions, Shim-pack Scepter LC columns are fully scalable between UHPLC, HPLC and preparative LC making method transfer seamless between different laboratory instrumentation.
- Automated support functions utilizing digital technology, such as M2M, IoT, and Artificial Intelligence (AI), that enable higher productivity and maximum reliability.
- Allows a system to monitor and diagnose itself, handle any issues during data acquisition without user input, and automatically behave as if it were operated by an expert.
- Supports the acquisition of high-quality, reproducible data regardless of an operator’s skill level for both routine and demanding applications.
Control of Shimadzu’s Nexera, Prominence series by Waters’ Empower chromatography data software is now available through a collaboration between Waters and Shimadzu utilizing the “Open Interface Portal (OIP)” for multi-vendor hardware control.
Control of Shimadzu’s Nexera and Prominence series by Thermo Scientific™ Dionex™ Chromeleon™ Chromatography Data System (CDS) Software (hereafter referred to as "Chromeleon™") 7 is now available through a collaboration between Thermo Fisher Scientific Inc.
An intuitive, full-featured integrated HPLC/UHPLC, the i-Series offers the ultimate balance of performance and ease-of-use, making it ideal for both R&D and QC.
The evaporative light scattering detector (ELSD) is a general-purpose universal detector that can even detect components with no UV absorption, such as carbohydrates, lipids, surfactants, and synthetic polymers.
Exact Mass Database for Endogenous Metabolites contains multiple ready-to-use methods for comprehensive analysis of metabolites with different properties. It is based on the successful LC/MS/MS Method Packages for Primary Metabolites, Cell Culture Profiling, Lipid Mediators, Short Chain Fatty Acids, and Bile Acids, and provides a comprehensive list of 470 metabolites with retention times and exact mass information.
Inheriting the stability and extensibility that are the strengths of the Prominence series, the new RID-20A model of differential refractive index detector is designed with a new reference-cell auto-purge feature and validation support function.
Efficient, Easy to Use, Space Saving
Up to six fraction collectors can be connected simultaneously.
Compatible with many racks corresponding to the intended fraction volume.
Can accommodate up to 3,240 fractions (6 FRC-40s, 10 mm tubes).
World-class sensitivity meets diverse needs
The excellent basic performance of the Prominence series is further enhanced by the RF-20A/RF-20Axs fluorescence detectors, which offer world-class sensitivity, excellent ease of maintenance, and validation support functions.
Enhanced Sensitivity for Trace Analysis
The ELSD-LTII utilizes a high-efficiency LED and enhanced digital signal treatment to minimize noise and deliver optimum sensitivity for trace analysis.
The Nexera XS inert system offers the ideal solution for the separation of biomolecules by combining the elevated pressure tolerance of a UHPLC system with complete inertness of the sample flow path, ensured by the absence of wetted metal surfaces and offering ultra-high resistance to corrosion.
Nexera lite inert is a robust HPLC system that eliminates the risk of corrosion by high-salt mobile phases and sample adsorption onto metal surfaces. It improves the data quality of protein analysis in biological samples with superior reproducibility, without any special considerations for stable and long-term use.
|Low-pressure gradient unit||Low-pressure gradient unit for LC-40D/40D XR/40D XS/40D X3|
|Reservoir selection valve||Two-solvent switching unit to be incorporated in solvent delivery unit|
|FCV-11AL||The mobile phase switching valve of 3 flow lines that connects to solvent delivery unit (external)|
|FCV-11ALS||The mobile phase switching valve of 1 flow line that connects to solvent delivery unit (external)|
|Automatic rinsing kit||Automatic rinsing kit for plunger seal cleaning|
|Mixer MR 20 μL||High-efficiency mixer for high-pressure gradient system (volume 20 μL)|
|Mixer MR 40 μL||High-efficiency mixer for high-pressure gradient system (volume 40 μL)|
|Mixer MR 100 μL||High-efficiency mixer for high-pressure gradient system (volume 100 μL)|
|Mixer MR 180 μL||High-efficiency mixer for high-pressure gradient system (volume 180 μL)|
Mixer MR 40 μL LPGE
|High-efficiency mixer for high-pressure gradient system (volume 40 μL)|
|Mixer MR 300 μL LPGE||High-efficiency mixer for high-pressure gradient system (volume 300 μL)|
|Sample loop||50 μL||Sample loop for 50 μL injection (standard configuration of SIL-40 XR/40C XR/40C XS/40C X3)|
|100 μL||Sample loop for 100 μL injection (standard configuration of SIL-40/40C)|
||Sample loop to increase the injection volume up to 500 μL
(Connect sample loop 100 μL)
|2000 μL||Sample loop to increase the injection volume up to 2 mL
(Connect sample loop 100 μL)
|Dual-injection kit||Tubing kits for dual injection|
|Sample loop for
|5 μL||Sample loop for loop injection mode (volume 5 μL)|
|20 μL||Sample loop for loop injection mode (volume 20 μL)|
|50 μL||Sample loop for loop injection mode (volume 50 μL)|
|1.5 mL||Plate for 1.5 mL sample vial (54)|
|Sample plate||1 mL||Plate for 1 mL sample vial (84)|
|4 mL||Plate for 4 mL sample vial (28)|
|10 mL||Plate for 10 mL sample vial (12)|
|Identification label affixed to the 96-well microtiter plate (100 set)|
|Identication label affixed to the 96-well deep-well plate (100 set)|
|Identication label affixed to the 384-well microtiter plate (100 set)|
|Identification label affixed to the 384-well deep-well plate (100 set)|
|UHPLC cell||Flow cell for high-speed analysis (volume 8 μL)|
|Semi-micro cell||Flow cell for semi-micro analysis (volume 2.5 μL)|
|Conventional cell||Flow cell with the same cell volume (12 μL) as standard cell of SPD-20A and SPD-M20A|
|Inert cell||Inert-type flow cell with metal-less wetted parts|
|Preparative cell||Preparative flow cell with variable optical path length|
|Micro flow cell||Flow cell for micro analysis (volume 0.21 μL)|
|Maximum pressure cell||High-pressure resisting flow cell for Nexera™ UC|
|Solvent recycle valve||Valve to recycle mobile phase by attaching to SPD-40/40V|
|Mobile phase monitor (controller)||
MPM-40 controller to monitor remaining mobile phase in real-time
Up to six bottle holders can be connected
|Reservoir tray||Reservoir tray for up to 8 bottles (1L)|
|AD board||Board for analog–digital conversion. It takes in detector signals as analog signals.|
|Optical cable connector
|The board to expand the number of optical cable connector channels to 12ch from 8ch
(standard) by attaching to SCL-40/CBM-40
|FCV-DR||Drive unit and control board for incorporating valve into CTOs (1 FCV valve is required separately)|
|FCV-0206||2-position 6-port valve (Maximum pressure: 44 MPa)|
|FCV-0607||6-position 7-port valve (Maximum pressure: 44 MPa)|
|FCV-0206H||2-position 6-port valve (Maximum pressure: 80 MPa)|
|FCV-0607H||6-position 7-port valve (Maximum pressure: 80 MPa)|
|FCV-0206H3||2-position 6-port valve (Maximum pressure: 130 MPa)|
|FCV-0607H3||6-position 7-port valve (Maximum pressure: 130 MPa)6|