Shimadzu at ASMS 2022

Events and Presentations at ASMS 2023

Event Details

  • June 4th-8th
  • Booth: #706
  • Suite: Grand Ballroom GHI
  • Houston, Texas
  • ASMS Link

Breakfast Seminars

Location: George R. Brown Convention Center
Monday to Wednesday: Room 320BC
Thursday: Room 320A


Resource-efficient MALDI MSI

Fast, cost-efficient and reproducible workflows for MALDI MSI experiments is one of the most important challenges for the technology to increase acceptance throughout the market. We introduce you to our workflow for high-spatial MALDI imaging under inert conditions. Matrix preparation techniques are carefully optimized and evaluated for the iMLayer AERO (application by spraying) using the MALDI 8030 benchtop instrumentation. The linear MALDI instrument is operated under fixed settings allowing for cost and time efficient survey experiments by its speed of analysis. Matrix choice and deposition parameters can quickly assessed. The method with the best performance is then used to prepare samples for the better performing MALDI instrument, the MALDI 7090, which provides higher spatial and mass resolution.

The workflow proves to be a very efficient tool for developing a matrix spraying method tailored to a specific sample in a very short time.

Martina Marchetti-Deschmann1
TU Wien, Institute of Chemical Technologies and Analytics, Getreidemarkt 9/164, Vienna, Austria; martina.marchetti-deschmann@tuwien.ac.at


Setting up a new Mass Spectrometry Core Facility - Establishing workflows for a diverse userbase

The Chemical and Biophysical Instrumentation Center (CBIC) in the Yale Chemistry Department hosts over 30 instruments with a broad range of analytical applications. The mass spectrometry subsection was created in 2019/2020 and provides now a variety of MS based measurements for research groups in Chemistry, Molecular Biophysics and Biochemistry, Biology, Chemical Engineering, Medicine, Archeology and beyond. The availability of GC-FID/MS, quantitative and qualitative LCMS, and MALDI MS under one roof allows to provide researchers with the technique most suitable to their analytical needs. In this seminar, Dr. Fabian Menges will present challenges and opportunities in this work and will report on some recent projects.


Dr. Fabian Menges


What’s in your toolbox? Add a SPARQ to Your Research!

“What’s in your toolbox?” is an analogy that I frequently use to describe the decision making process of method development and instrumental analysis. This analogy references not only the physical tools that are available, but also knowledge and personnel. Some of the physical tools that one might have available include separation science, spectroscopy, physical measurements tools, and of course mass spectrometry. Many sectors of academia and non-Ph.D. granting institutions often struggle to afford the instrumentation required for successful and innovative analysis. Through more than $2.5M in grant funding over the last 5 years, Dr. Tucker and his collaborators have equipped the lab with HPLC-DAD/RID, an EDX, a UV/Vis/NIR, two LCMS, and two GCMS instruments. One of the largest struggles for smaller institutions though is learning how to expertly use a variety of instruments, efficiently manage usage requests, and sufficiently train students to become independent operators of the equipment. During this seminar, we will discuss the most important tool Shimadzu provides that enables research at a higher level which frequently goes unnoticed and unrecognized in terms of its level of importance – the collaboration.

Kevin Tucker, Ph.D. and Kendra Selby


Liquid Chromatography, Supercritical Fluid Chromatography and Vacuum Differential Mobility Spectrometry - Mass Spectrometry for the Analysis of Complex Samples

Nowadays sensitive identification and selective quantification of low molecular weight compounds relies on the combination of separation sciences and mass spectrometric detection. While liquid chromatography (LC) with electrospray ionization remains the most used separation technique. supercritical fluid chromatography (SFC-MS) offers an attractive alternative to (LC-MS) as the chromatographic conditions can be decoupled from the ionization conditions and the benefits will be discussed.

Separation of isomeric or isobaric analytes remains a challenge and ion mobility as gained of interest to separate isomers, to improve selectivity and to reduce analysis time. The potential of vacuum Differential Mobility Spectrometry – Mass Spectrometry (vDMS-MS) for reducing LC analysis time while maintaining good selectivity is presented for the analysis of 14 diastereomeric pyrrolizidine alkaloids (PAs), in tea samples. The performance of the LC-vDMS-SIM/MS approach will be discussed and compared to a conventional LC-SRM/MS method and two SFC-SRM/MS methods.

Maria Fernanda Cifuentes Girard1, Patrick Knight2, and Gérard Hopfgartner1
1. Life Sciences Mass Spectrometry, Department of Inorganic and Analytical Chemistry, University of Geneva, 24 Quai Ernest Ansermet, CH-1211 Geneva 4, Switzerland
2. Shimadzu Research Laboratory, Wharfside, Trafford Wharf Road, Manchester M17 1GP, United Kingdom.

Oral Presentations

Session Date/Time Title
MOC AM Monday, June 5, 2023 
10:10 AM
Spatial chemistry of the developing brain with defective mitochondria
MOD PM Monday, June 5, 2023 
3:30 PM
Analysis of yeast lipids exposed to low temperature stress using data-independent acquisition-based lipidomics
ThOG PM Thursday, June , 2023
3:10 PM
High Throughput Analysis of Isomeric Drug of Abuse in Human Urine Samples by Liquid Chromatography Vacuum Differential Mobility Spectrometry-Mass Spectrometry


Below is a list of posters and presentations we have scheduled for ASMS 2023.
Please check back after the conference to download files.

Monday, June 5, 2023
Session Title
MP 054 Fast determination of plasma catecholamines and metanephrines by solid-phase extraction and liquid chromatography–tandem mass spectrometry applicated to clinical assay
MP 165 Metabolite profiling applied to biomarker discovery in pancreatic cancer using high resolution LC-MS/MS
MP 181 Molecular Weight Determination and Sequence Confirmation of Oligonucleotides by LCMS-9030 Quadrupole Time-of-Flight (Q-TOF) Mass Spectrometer
MP 209 Determination of nitrofuran metabolite residues in shrimp by LC-MS/MS
MP 211 Analysis of Residual Pesticides in Strawberries using the Quadrupole Time-of-Flight Mass Spectrometer
MP 212 Analysis of Veterinary Drugs in Chicken Tenders using the Quadrupole Time-of-Flight Mass Spectrometer
MP 213 Analysis of Per- and Polyfluoroalkyl Substances (PFAS) in Food Samples by LC-MS/MS
MP 214 Development of high sensitivity and separation detection method for ciguatoxin analogues by LC/MS/MS
MP 221 Multi-Residue Pesticide Analysisin Cumin seeds using GC-MS/MS
MP 223 Simplifying Dioxins Analysis in Foods and Feeds Using GC-MS/MS in Compliant with the EU Commission Regulation
MP 228 Quantitation of N-nitrosamine impurities in dietary supplement by using LC-MS/MS
MP 311 Ultra-fast Online SPE Applicable to a Wide Range of Compounds with Various Hydrophobicity for High-throughput Analysis using Multiplexed 4-channel 2D-LC-MS/MS
MP 344 Distribution analysis of galanthamine, a plant alkaloid, by MS imaging
MP 468 A quantitative discrimination study of recycled cashmere fibers using MALDI-TOF MS
MP 471 Rapid Differentiation Between Mixed A1/A2 and A2 Only Cow Milk Using MALDI-TOF-MS
MP 483 Multi-laser induced MALDI post ionization (MALDI-2+) on a MALDI/ESI dual source
MP 498 Quantitative analysis of Omega Fatty acids in human serum using Gas Chromatograph Mass Spectrometer
MP 503 Direct Probe Ionisation Mass Spectrometry applied to biomarker discovery in pancreatic cancer
MP 519 Automated bacterial sample preparation from Agar to MALDI target for routine bacterial identification
MP 525 Simplified molecular imaging analysis of excreted microbial metabolites using a benchtop MALDI-TOF system
MP 608 Peptide Mapping of a Monoclonal Antibody Using an Integrated Protein Digestion LCMS Platform (Perfinity-QTOF LCMS-9030)
MP 641 Characterizing Macromolecular Dipole Moments via Differential Ion Mobility Spectrometry with Linked Field/Pressure Scans


Tuesday, June 6, 2023
Session Title
TP 114 Media Component Analysis during Human Primary T Cell Culture using a Triple Quadrupole Mass Spectrometer
TP 143 Simultaneous analysis of immunosuppressive drugs in whole blood samples using LC-MS/MS
TP 160 Quantitation of endogenous steroids in serum using dried blood spot serum separator card and triple quadruple mass spectrometry
TP 239 PY-GCMS analysis of microplastics in environmental samples using nitrogen as an alternative carrier gas
TP 257 Characterization of Unsaturated Fatty Acids in Negative OAD-MS/MS using LCMS-9050
TP 261 Analysis of fatty acid content in rice by GC-MS/MS combined with metabolite database
TP 351 Lipid Annotation for MALDI Imaging using Isotope Pattern, Spectral Pattern and Co-Localization Information
TP 399 Prototype Development of a Digital Linear Ion Trap based Portable GCMS for VOCs Analysis
TP 429 Development of a high-resolution U-shaped mobility analyzer (UMA) and its applications
TP 474 Wide-Target Analysis of Yogurt Using Triple Quadrupole LC-MS/MS
TP 507 Determination of molecular weight of small interfering nucleotides siRNA by LCMS
TP 511 Accelerating Oligonucleotide Research Using Novel Bioinert LC, QTOF and TQ LC-MS
TP 521 Fast acquisition of DDA-MS/MS of oligonucleotides and the novel spectral merging algorithm for better assignment of sequence information
TP 529 An oligonucleotide impurity analysis workflow with the new software that calculates percentage impurity based on summed XIC peak area
TP 728 Detection and quantitation of benzodiazepines in less than 3 min using Probe Electrospray Ionization mass spectrometry and isotope dilution approach
TP 731 Drugs of abuse in hair: high speed and sensitivity demands for LC-MS/MS


Wednesday, June 7, 2023
Session Title
WP 019 Rapid Identification of Double Bond Positions of Lipids in Butter by using Probe ESI Q-TOF LCMS-9050 and OAD-MS/MS
WP 042 Analyses of chemical modifications in therapeutic antibodies by high resolution multi-turn TOF-MS system
WP 053 Development of a multiplex ultra-sensitive LC-MS method for the quantification of Alzheimer’s disease main blood biomarkers (pTau, Tau, APOE, Aβ, alpha-synuclein): a challenge
WP 155 Quantification of Sazetidine-A from Rat Brain and Plasma for the Treatment of Tinnitus
WP 158 Determination of Ethyl Glucuronide in plasma by ATLAS-LEXT NHD combined with LC-MS/MS
WP 166 Metabolism study of the novel cathinone derivative 3-MMC combining three in vitro approaches, LC-HRMS acquisition and molecular networking tools
WP 191 An alternative approach for ASTM D7845 in determining chemical species in Marine fuel oil by Gas Chromatography/Mass Spectrometry
WP 195 Specific determination of non-ionic surfactants in drinking-, waste- and surface water with high resolution mass spectrometry
WP 227 Rapid Characterization of Alkaloids using Probe ESI Q-TOF LCMS-9050 in OAD-MS/MS
WP 304 Untargeted PFAS identification and targeted PFAS library screening workflows for groundwater analysis using a QTOF mass spectrometer
WP 328 Identification and visualization of the spatio-temporal distribution of phosphatidic acids in bladder cancer
WP 329 Spatial Mapping of Lipids and Elements by Mass Microscopy and Integration with LA-ICP-MS in the Diabetic Mouse Pancreata
WP 361 Enhanced screening for Active Pharmaceutical Ingredients (APIs) through the integration of a single quadrupole mass spectrometer
WP 362 Quantitative Analysis of Azido Impurities in Five Sartan Drug Substances using a Triple Quadrupole Mass Spectrometer
WP 419 Development of a compact TLC sampler for MS and its applications
WP 484 Low level quantitation of seven N-nitrosamines in Monoclonal antibody (mAb) formulations by using LC-MS/MS
WP 490 Highly sensitive quantitation of N-nitroso-propranolol in Propranolol hydrochloride formulation and its placebo by using LC-MS/MS
WP 501 Quantification of Psilocybin and Psilocin Content Variety in Psilocybe cubensis Strains with LC-MS
WP 520 Identifying Double-Bond-Positions of Phospholipids in Mouse Liver by Using Simultaneous Positive/Negative Ion Switching Analysis of LCMS-9050 and OAD-MS/MS
WP 577 A biological model of the ageing metabolome reveals potential clinically relevant biomarkers
WP 681 Simultaneous quantitation of multiple excipients in biological formulation by using LC-MS/MS


Thursday, June 8, 2023
Session Title
ThP 073 Analysis of Per- and Poly-fluoroalkylated Substances (PFAS) Specified in EPA Method 1633 Using Triple Quadrupole LC-MS/MS
ThP 095 Water quality determination: a myriad of analysis simplified
ThP 096 Determination of multiresidue pesticides in Arabian Dates using LC and GC Triple Quadrupole Mass Spectrometry
ThP 099 A Highly sensitive method for the determination of carbamates in water as per ASTM D-7645 by LCMS-8045
ThP 131 Determination of authenticity of Manuka honey by MALDI-TOF mass spectrometry
ThP 139 Comprehensive analysis of functional ingredients using LC-MS/MS
ThP 141 Rapid detection of natural plant toxins using probe ESI unit combined with quadrupole time-of-flight mass spectrometer
ThP 277 Visualizing the spatial distribution of flavonoids and phenolic acids in the tuber root of Tetrastigma hemsleyanum using AP-MALDI-MSI
ThP 280 Distribution of active pharmaceutical ingredients in Forthysia Suspensa and quality control with mass spectrometry imaging
ThP 322 Dissecting Immunometabolism of Dilated Cardiomyopathy (DCM) on delta-sarcoglycan deficient hamster model with thoracic Imaging Mass Spectrometry (tIMS)
ThP 419 Advanced sample preparation in LC/MS bioanalysis using new solid phase extraction
ThP 449 Development of an MRM based phospholipid profiling method in human plasma using an inert C18 column
ThP 473 Integrated analysis of LC/MS and GC/MS data in NASH and NAFLD model mice
ThP 477 Investigating systemic gut microbiome derived metabolites from IL18-/- mice as potential mechanisms in health and disease
ThP 571 Synthetic modified oligonucleotides analysis using a matrix-assisted laser desorption/ionization digital-ion-trap mass spectrometer (MALDI-DIT-MS)